MPC1 pyruvate transporter MPC1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MPC1
Official Full Name: pyruvate transporter MPC1
Primary source: SGD:S000003048
Locus tag: YGL080W
See related: AllianceGenome:SGD:S000003048; FungiDB:YGL080W; VEuPathDB:YGL080W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FMP37
Summary: Enables pyruvate transmembrane transporter activity. Involved in mitochondrial pyruvate transmembrane transport. Located in mitochondrial inner membrane. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in mitochondrial pyruvate carrier deficiency. Orthologous to several human genes including MPC1L (mitochondrial pyruvate carrier 1 like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MPC1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (358636..359028)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes.
Title: NMR and Patch-Clamp Characterization of Yeast Mitochondrial Pyruvate Carrier Complexes.
MPC is a hetero-dimer, not a multimeric complex. When not engaged in hetero-dimers, the yeast Mpc proteins can also form homo-dimers that are, however, inactive.
Title: The yeast mitochondrial pyruvate carrier is a hetero-dimer in its functional state.
while expression of Mpc1 is not dependent on the carbon source, expression of Mpc2 and Mpc3 is specific to fermentative or respiratory conditions, respectively. This gives rise to two alternative carrier complexes
Title: Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes.
Mpc1 (YGL080W )and Mpc2 (YHR162W) associate to form a complex in the inner mitochondrial membrane; loss of Mpc1 results in defective mitochondrial pyruvate uptake; data demonstrate that Mpc1 and Mpc2 form an essential part of the mitochondrial pyruvate carrier
Title: A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.
study concludes that the mitochondrial pyruvate carrier is composed of Mpc1(Ygl080w) and either Mpc2 (Yhr162w) or Mpc3 (Ygr243w); members of the MPC family were found in the inner mitochondrial membrane; mutants lacking MPC proteins showed severe defects in mitochondrial pyruvate uptake
Title: Identification and functional expression of the mitochondrial pyruvate carrier.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables pyruvate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables pyruvate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial pyruvate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial pyruvate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial pyruvate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial pyruvate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pyruvate transporter MPC1

NP_011435.1

Highly conserved subunit of mitochondrial pyruvate carrier (MPC); MPC is a mitochondrial inner membrane complex that mediates pyruvate uptake and comprises Mpc1p and Mpc2p during fermentative growth, or Mcp1p and Mpc3p during respiratory growth; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog MPC1 is associated with lactic acidosis and hyperpyruvatemia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

358636..359028

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180945.1 → NP_011435.1 TPA: pyruvate transporter MPC1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011435.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VU64, P53157

UniProtKB/TrEMBL

A6ZU99, B3LHE6, C7GW36, C8Z8G7, G2WE19, N1P5G4

Conserved Domains (1) summary

pfam03650
Location:13 → 121

MPC; Uncharacterized protein family (UPF0041)