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    AEP2 Aep2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855325, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AEP2
    Official Full Name
    Aep2p
    Primary source
    SGD:S000004895
    Locus tag
    YMR282C
    See related
    AllianceGenome:SGD:S000004895; FungiDB:YMR282C; VEuPathDB:YMR282C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ATP13
    Summary
    Predicted to enable RNA binding activity. Involved in mitochondrial translational initiation. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AEP2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (833356..835098, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcription factor CAT8 Neighboring gene N-acetylglucosaminylphosphatidylinositol deacetylase Neighboring gene tRNA A64-2'-O-ribosylphosphate transferase Neighboring gene tRNA-Tyr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of a nuclear aep2 mutation in Saccharomyces cerevisiae by a base substitution in the 5'-untranslated region of the mitochondrial oli1 gene encoding subunit 9 of ATP synthase. Ellis TP, et al. Genetics, 1999 Apr. PMID 10101162, Free PMC Article
    2. The mature AEP2 gene product of Saccharomyces cerevisiae, required for the expression of subunit 9 of ATP synthase, is a 58 kDa mitochondrial protein. Finnegan PM, et al. FEBS Lett, 1995 Jul 24. PMID 7635208
    3. Characterization of a yeast nuclear gene, AEP2, required for accumulation of mitochondrial mRNA encoding subunit 9 of the ATP synthase. Finnegan PM, et al. Curr Genet, 1991 Jul. PMID 1718609
    4. Incompatibility of nuclear and mitochondrial genomes causes hybrid sterility between two yeast species. Lee HY, et al. Cell, 2008 Dec 12. PMID 19070577
    5. ATP13, a nuclear gene of Saccharomyces cerevisiae essential for the expression of subunit 9 of the mitochondrial ATPase. Ackerman SH, et al. FEBS Lett, 1991 Jan 28. PMID 1825065

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational initiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aep2p
    NP_014009.1
    • Mitochondrial protein; likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      833356..835098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182789.1 → NP_014009.1  TPA: Aep2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014009.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5VQ50, C7GTL7, D6W0A9, P22136, P23115
      UniProtKB/TrEMBL
      N1P609
      Conserved Domains (1) summary
      pfam12921
      Location:317 → 427
      ATP13; Mitochondrial ATPase expression
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22136.3

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