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    PGA2 Pga2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855573, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PGA2
    Official Full Name
    Pga2p
    Primary source
    SGD:S000005093
    Locus tag
    YNL149C
    See related
    AllianceGenome:SGD:S000005093; FungiDB:YNL149C; VEuPathDB:YNL149C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein transport. Located in endoplasmic reticulum and nuclear envelope. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PGA2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (349367..349756, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Inn1p Neighboring gene DNA-directed RNA polymerase III subunit C31 Neighboring gene Alf1p Neighboring gene Sm-like protein LSM7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A survey of essential gene function in the yeast cell division cycle. Yu L, et al. Mol Biol Cell, 2006 Nov. PMID 16943325, Free PMC Article
    2. Members of the RSC chromatin-remodeling complex are required for maintaining proper nuclear envelope structure and pore complex localization. Titus LC, et al. Mol Biol Cell, 2010 Mar 15. PMID 20110349, Free PMC Article
    3. ATP synthase interactome analysis identifies a new subunit l as a modulator of permeability transition pore in yeast. Panja C, et al. Sci Rep, 2023 Mar 7. PMID 36882574, Free PMC Article
    4. Heme, A Metabolic Sensor, Directly Regulates the Activity of the KDM4 Histone Demethylase Family and Their Interactions with Partner Proteins. Konduri PC, et al. Cells, 2020 Mar 22. PMID 32235736, Free PMC Article
    5. Assigning function to yeast proteins by integration of technologies. Hazbun TR, et al. Mol Cell, 2003 Dec. PMID 14690591

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope HDA PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pga2p
    NP_014250.1
    • Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      349367..349756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182987.1 → NP_014250.1  TPA: Pga2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014250.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W133, P53903
      UniProtKB/TrEMBL
      A6ZRT4, B3LP05, C7GXV0, C8ZG79, G2WLV7, N1NWH5
      Conserved Domains (1) summary
      pfam07543
      Location:16 → 128
      PGA2; Protein trafficking PGA2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53903.3

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