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    Ackr2 atypical chemokine receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 59289, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ackr2provided by MGI
    Official Full Name
    atypical chemokine receptor 2provided by MGI
    Primary source
    MGI:MGI:1891697
    See related
    Ensembl:ENSMUSG00000044534 AllianceGenome:MGI:1891697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D6; CCR9; CCR10; Ccbp2; Cmkbr9
    Summary
    Enables C-C chemokine binding activity and C-C chemokine receptor activity. Acts upstream of or within signal transduction. Predicted to be located in several cellular components, including actin filament; cytosol; and nucleus. Predicted to be active in external side of plasma membrane. Is expressed in central nervous system; retina; and trophoblast giant cell. Orthologous to human ACKR2 (atypical chemokine receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 18.6), spleen adult (RPKM 7.1) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Ackr2 in Genome Data Viewer
    Location:
    9 F4; 9 72.71 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121727421..121740177)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121898355..121911075)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene HIG1 domain family, member 1A Neighboring gene STARR-positive B cell enhancer ABC_E3869 Neighboring gene predicted gene, 47112 Neighboring gene predicted gene, 47113 Neighboring gene STARR-seq mESC enhancer starr_25540 Neighboring gene cytochrome P450, family 8, subfamily b, polypeptide 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:121836139-121836440 Neighboring gene STARR-positive B cell enhancer mm9_chr9:121837482-121837783 Neighboring gene RIKEN cDNA 1700048O20 gene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC130576

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables C-C chemokine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables C-C chemokine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scavenger receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables scavenger receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    atypical chemokine receptor 2
    Names
    C-C chemokine receptor D6
    D6 beta-chemokine receptor
    chemokine decoy receptor D6
    chemokine-binding protein 2
    chemokine-binding protein D6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276719.2NP_001263648.1  atypical chemokine receptor 2

      See identical proteins and their annotated locations for NP_001263648.1

      Status: VALIDATED

      Source sequence(s)
      AC164092, AC165080
      Consensus CDS
      CCDS23640.1
      UniProtKB/Swiss-Prot
      O08707, Q8CEG1
      Related
      ENSMUSP00000148966.2, ENSMUST00000214340.2
      Conserved Domains (2) summary
      cd14964
      Location:4872
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:46322
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. NM_021609.5NP_067622.2  atypical chemokine receptor 2

      See identical proteins and their annotated locations for NP_067622.2

      Status: VALIDATED

      Source sequence(s)
      AC164092, AC165080
      Consensus CDS
      CCDS23640.1
      UniProtKB/Swiss-Prot
      O08707, Q8CEG1
      Related
      ENSMUSP00000050119.4, ENSMUST00000050327.5
      Conserved Domains (2) summary
      cd14964
      Location:4872
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:46322
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      121727421..121740177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512203.5XP_006512266.1  atypical chemokine receptor 2 isoform X1

      See identical proteins and their annotated locations for XP_006512266.1

      UniProtKB/Swiss-Prot
      O08707, Q8CEG1
      Conserved Domains (2) summary
      cd14964
      Location:4872
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:46322
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily