Nrbp2 nuclear receptor binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrbp2provided by MGI
Official Full Name: nuclear receptor binding protein 2provided by MGI
Primary source: MGI:MGI:2385017
See related: Ensembl:ENSMUSG00000075590 AllianceGenome:MGI:2385017
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in negative regulation of neuron apoptotic process and neuron differentiation. Located in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; brain; reproductive system; and respiratory system. Orthologous to human NRBP2 (nuclear receptor binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 123.7), CNS E18 (RPKM 73.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 35.35 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (75957364..75963539, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (76085515..76091690, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that NRBP2 protein levels increase as neural progenitor cells differentiate, and its down regulation renders neural progenitor cells more vulnerable to apoptosis, which suggest a role in stem cell survival.
Title: Nuclear receptor binding protein 2 is induced during neural progenitor differentiation and affects cell survival.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of macroautophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nuclear receptor-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358359.1 → NP_001345288.1 nuclear receptor-binding protein 2

Status: VALIDATED

Source sequence(s)

AC116487, BC068117, BU610466, CJ070129

Consensus CDS

CCDS27561.2

UniProtKB/Swiss-Prot

Q8R3M0, Q91V36

Related

ENSMUSP00000154287.2, ENSMUST00000228366.3

Conserved Domains (1) summary

cd14035
Location:44 → 305

PK_MADML; Pseudokinase domain of MLF1-ADaptor Molecule-Like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

75957364..75963539 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_144847.1: Suppressed sequence

Description

NM_144847.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.