KCS1 inositol polyphosphate kinase KCS1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: KCS1
Official Full Name: inositol polyphosphate kinase KCS1
Primary source: SGD:S000002424
Locus tag: YDR017C
See related: AllianceGenome:SGD:S000002424; FungiDB:YDR017C; VEuPathDB:YDR017C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables diphosphoinositol pentakisphosphate kinase activity; inositol hexakisphosphate kinase activity; and inositol-1,3,4,5,6-pentakisphosphate kinase activity. Involved in inositol phosphate biosynthetic process and regulation of inositol phosphate biosynthetic process. Located in cytoplasm. Orthologous to human IP6K1 (inositol hexakisphosphate kinase 1); IP6K2 (inositol hexakisphosphate kinase 2); and IP6K3 (inositol hexakisphosphate kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See KCS1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (479115..482267, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae via KCS1 activity.
Title: Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae.
Plc1p, Arg82p, and Kcs1p are enzymes involved in inositol pyrophosphate synthesis and are essential for phosphate regulation and polyphosphate accumulation
Title: Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diphosphoinositol pentakisphosphate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol hexakisphosphate 1-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol hexakisphosphate 5-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol hexakisphosphate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,3,4,5,6-pentakisphosphate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,4,5-trisphosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in inositol phosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inositol phosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inositol polyphosphate kinase KCS1

NP_010300.3

EC 2.7.4.21

Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response, RNA polymerase I-mediated rRNA transcription and telomere maintenance; phosphorylated by the AMPK Snf1p, leading to reduced levels of pyrophosphorylated IP7, increased filamentous and invasive growth and increased cell elongation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

479115..482267 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180325.3 → NP_010300.3 TPA: inositol polyphosphate kinase KCS1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010300.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VS03, P89899, Q12494, Q7LGR2

UniProtKB/TrEMBL

A6ZXY1, C8Z4T7, N1P6B8

Conserved Domains (1) summary

pfam03770
Location:759 → 957

IPK; Inositol polyphosphate kinase