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    Dpp8 dipeptidylpeptidase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315758, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dpp8provided by RGD
    Official Full Name
    dipeptidylpeptidase 8provided by RGD
    Primary source
    RGD:1310901
    See related
    EnsemblRapid:ENSRNOG00000019105 AllianceGenome:RGD:1310901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human DPP8 (dipeptidyl peptidase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 407.7), Kidney (RPKM 261.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Dpp8 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (74445815..74501017)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (65550620..65605828)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (70521782..70576180)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 14 Neighboring gene 3-hydroxyacyl-CoA dehydratase 3 Neighboring gene ATP synthase membrane subunit DAPIT, mitochondrial-like Neighboring gene immunoglobulin superfamily, DCC subclass, member 4 Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like Neighboring gene immunoglobulin superfamily, DCC subclass, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminopeptidase activity  
    enables dipeptidyl-peptidase activity  
    enables dipeptidyl-peptidase activity  
    enables serine-type peptidase activity  
    Process Evidence Code Pubs
    involved_in negative regulation of programmed cell death  
    involved_in proteolysis  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  

    General protein information

    Preferred Names
    dipeptidyl peptidase 8
    NP_001381020.1
    NP_001381021.1
    NP_001381022.1
    XP_006243316.1
    XP_006243318.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394091.1NP_001381020.1  dipeptidyl peptidase 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J5D8, D3ZHQ1
      Related
      ENSRNOP00000084987.2, ENSRNOT00000111343.2
      Conserved Domains (2) summary
      pfam00326
      Location:680885
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:169589
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    2. NM_001394092.1NP_001381021.1  dipeptidyl peptidase 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J5D8, D3ZHQ1
      Conserved Domains (2) summary
      pfam00326
      Location:680885
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:169589
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    3. NM_001394093.1NP_001381022.1  dipeptidyl peptidase 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      Conserved Domains (2) summary
      pfam00326
      Location:671876
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:160580
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RNA

    1. NR_172080.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      74445815..74501017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243256.5XP_006243318.1  dipeptidyl peptidase 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A305, A6J5D9
      Conserved Domains (2) summary
      pfam00930
      Location:169589
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:680716
      Abhydrolase; alpha/beta hydrolases
    2. XM_006243254.3XP_006243316.1  dipeptidyl peptidase 8 isoform X1

      See identical proteins and their annotated locations for XP_006243316.1

      UniProtKB/TrEMBL
      A6J5D8, D3ZHQ1
      Conserved Domains (2) summary
      pfam00326
      Location:680885
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:169589
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
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