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    Oas1b 2-5 oligoadenylate synthetase 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246268, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Oas1bprovided by RGD
    Official Full Name
    2-5 oligoadenylate synthetase 1Bprovided by RGD
    Primary source
    RGD:708393
    See related
    EnsemblRapid:ENSRNOG00000033220 AllianceGenome:RGD:708393
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable double-stranded RNA binding activity. Predicted to be involved in innate immune response; interleukin-27-mediated signaling pathway; and negative regulation of viral genome replication. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol; membrane; and nucleoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human OAS1 (2'-5'-oligoadenylate synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 51.7), Lung (RPKM 40.3) and 9 other tissues See more
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    Genomic context

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    See Oas1b in Genome Data Viewer
    Location:
    12q16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41385184..41395891, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35724561..35735271, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41255762..41266430, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 2 ' -5 ' oligoadenylate synthetase 1H Neighboring gene 2 ' -5 ' oligoadenylate synthetase 1F Neighboring gene 2'-5' oligoadenylate synthetase 1E Neighboring gene 2 ' -5 ' oligoadenylate synthetase 1K

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human T-cell leukemia virus type 1 Tax protein stimulates the interferon-responsive enhancer element via NF-kappaB activity. Shimizu T, et al. FEBS Lett, 2003 Mar 27. PMID 12650929
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC108585

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables 2'-5'-oligoadenylate synthetase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-27-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inactive 2'-5'-oligoadenylate synthase 1B
    Names
    (2-5')oligo(A) synthase 1B
    2'5' oligoadenylate synthetase-2
    2-5A synthase 1B
    25 oligoadenylate synthetase-2
    NP_653353.2
    XP_038944996.1
    XP_038944997.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144752.2 → NP_653353.2  inactive 2'-5'-oligoadenylate synthase 1B

      See identical proteins and their annotated locations for NP_653353.2

      Status: PROVISIONAL

      Source sequence(s)
      BC091121
      UniProtKB/Swiss-Prot
      O70522, Q5BKD0
      UniProtKB/TrEMBL
      A0A8L2PZR9
      Related
      ENSRNOP00000042591.5, ENSRNOT00000048782.6
      Conserved Domains (2) summary
      cd05400
      Location:27 → 176
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:164 → 347
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      41385184..41395891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089068.2 → XP_038944996.1  inactive 2'-5'-oligoadenylate synthase 1B isoform X1

      Conserved Domains (1) summary
      pfam10421
      Location:31 → 216
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    2. XM_039089069.2 → XP_038944997.1  inactive 2'-5'-oligoadenylate synthase 1B isoform X2

      Conserved Domains (1) summary
      pfam10421
      Location:4 → 189
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    RNA

    1. XR_005491597.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BKD0.1 GenPept UniProtKB/Swiss-Prot:Q5BKD0

    Gene LinkOut

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