U.S. flag

An official website of the United States government

Some NLM-NCBI services and products are experiencing heavy traffic, which may affect performance and availability. We apologize for the inconvenience and appreciate your patience. For assistance, please contact our Help Desk at info@ncbi.nlm.nih.gov.

Links from GEO Profiles

    • Showing Current items.

    Kpnb1 karyopherin subunit beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 16211, updated on 4-Jan-2025

    Summary

    Official Symbol
    Kpnb1provided by MGI
    Official Full Name
    karyopherin subunit beta 1provided by MGI
    Primary source
    MGI:MGI:107532
    See related
    Ensembl:ENSMUSG00000001440 AllianceGenome:MGI:107532
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IPOB; Impnb
    Summary
    Enables Hsp90 protein binding activity; importin-alpha family protein binding activity; and nuclear import signal receptor activity. Acts upstream of or within ribosomal protein import into nucleus. Located in cytoplasmic stress granule. Part of protein-containing complex. Is expressed in several structures, including gonad; metencephalon alar plate; neural retina; pancreas; and telencephalon. Orthologous to human KPNB1 (karyopherin subunit beta 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 73.8), placenta adult (RPKM 41.1) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kpnb1 in Genome Data Viewer
    Location:
    11 60.95 cM; 11 D
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97050536..97078718, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97159710..97187892, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene T-box 21 Neighboring gene STARR-positive B cell enhancer ABC_E8446 Neighboring gene STARR-positive B cell enhancer ABC_E8447 Neighboring gene TBK1 binding protein 1 Neighboring gene microRNA 7235 Neighboring gene STARR-positive B cell enhancer ABC_E1842 Neighboring gene STARR-positive B cell enhancer ABC_E910 Neighboring gene aminopeptidase puromycin sensitive Neighboring gene predicted gene 11592

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC8315

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp90 protein binding PubMed 
    enables enzyme binding  
    enables importin-alpha family protein binding PubMed 
    enables kinesin binding  
    enables nuclear import signal receptor activity  
    enables nuclear import signal receptor activity PubMed 
    enables nuclear import signal receptor activity  
    enables nuclear localization sequence binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein domain specific binding  
    enables protein-containing complex binding  
    enables small GTPase binding  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus  
    involved_in NLS-bearing protein import into nucleus  
    involved_in RNA import into nucleus  
    involved_in astral microtubule organization  
    involved_in astral microtubule organization  
    involved_in establishment of mitotic spindle localization  
    involved_in establishment of mitotic spindle localization  
    involved_in mitotic chromosome movement towards spindle pole  
    involved_in mitotic chromosome movement towards spindle pole  
    involved_in mitotic metaphase chromosome alignment  
    involved_in mitotic metaphase chromosome alignment  
    involved_in mitotic spindle assembly  
    involved_in mitotic spindle assembly  
    involved_in protein import into nucleus  
    acts_upstream_of_or_within protein import into nucleus PubMed 
    acts_upstream_of_or_within protein import into nucleus PubMed 
    involved_in protein import into nucleus  
    involved_in protein import into nucleus  
    acts_upstream_of_or_within ribosomal protein import into nucleus PubMed 
    involved_in ribosomal protein import into nucleus  
    Component Evidence Code Pubs
    part_of NLS-dependent protein nuclear import complex  
    is_active_in cytoplasm  
    is_active_in cytoplasm  
    located_in cytoplasmic stress granule PubMed 
    located_in cytosol  
    located_in cytosol PubMed 
    located_in endoplasmic reticulum tubular network  
    located_in endoplasmic reticulum tubular network  
    located_in nuclear envelope  
    located_in nuclear membrane  
    located_in nuclear membrane  
    part_of nuclear pore  
    located_in nucleoplasm  
    located_in nucleoplasm PubMed 
    is_active_in nucleus  
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    importin subunit beta-1
    Names
    PTAC97
    SCG
    importin beta
    karyopherin (importin) beta 1
    nuclear factor p97
    pore targeting complex 97 kDa subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008379.3NP_032405.3  importin subunit beta-1

      See identical proteins and their annotated locations for NP_032405.3

      Status: VALIDATED

      Source sequence(s)
      AK147175, AL627445, BC052438
      Consensus CDS
      CCDS25316.1
      UniProtKB/Swiss-Prot
      P70168, Q62117, Q6GTI5
      UniProtKB/TrEMBL
      Q3TFE8, Q3UHW8, Q7TSZ6
      Related
      ENSMUSP00000001479.4, ENSMUST00000001479.5
      Conserved Domains (2) summary
      COG5215
      Location:2871
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:323354
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97050536..97078718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.