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    Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100301568, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aboprovided by RGD
    Official Full Name
    ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferaseprovided by RGD
    Primary source
    RGD:2307241
    See related
    EnsemblRapid:ENSRNOG00000086621 AllianceGenome:RGD:2307241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Abo2
    Summary
    Enables alpha-1,3-galactosyltransferase activity and glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity. Involved in several processes, including negative regulation of apoptotic process; response to nematode; and response to retinoic acid. Predicted to be located in Golgi cisterna membrane and extracellular region. Predicted to be active in Golgi apparatus and vesicle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; graft-versus-host disease; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 37.7), Heart (RPKM 31.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abo in Genome Data Viewer
    Location:
    3p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (30560172..30604758, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (10162087..10182835, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (4374679..4394374, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S13, pseudogene 10 Neighboring gene lipocalin 4-like 1 Neighboring gene endosulfine alpha, pseudogene 1 Neighboring gene surfeit 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The clinical implications of ABO blood groups in Pseudomonas aeruginosa sepsis in children. Kuo KC, et al. J Microbiol Immunol Infect, 2013 Apr. PMID 22464692
    2. [Clinical efficacies of ABO-incompatible adult liver transplantation]. Ju WQ, et al. Zhonghua Yi Xue Za Zhi, 2011 Sep 27. PMID 22321886
    3. Induction of red blood cell destruction by graft-derived antibodies after minor ABO-mismatched heart and lung transplantation. Hunt BJ, et al. Transplantation, 1988 Aug. PMID 3136561
    4. ABO compatibility and acute graft-versus-host disease following allogeneic bone marrow transplantation. Bacigalupo A, et al. Transplantation, 1988 Jun. PMID 3289150
    5. Influence of infectious diseases on hereditary polymorphism with respect to the blood groups of the ABO system. Bubnov YI, et al. Sov Genet, 1974 Nov 15. PMID 4375858

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-1,3-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables antigen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fucosylgalactoside 3-alpha-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to nematode IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histo-blood group ABO system transferase 2
    Names
    ABO blood group (alpha 1-3-N-acetylgalactosaminyltransferase, alpha 1-3-galactosyltransferase)
    ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase
    ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
    NAGAT 2
    a transferase
    b blood group galactosyltransferase
    b transferase
    blood group A glycosyltransferase 2
    cis-AB transferase 2
    fucosylglycoprotein 3-alpha-galactosyltransferase
    fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
    glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
    glycoprotein-fucosylgalactoside alpha-galactosyltransferase
    histo-blood group A transferase
    histo-blood group B transferase
    putative blood group A transferase T2
    transferase B, alpha 1-3-galactosyltransferase)
    NP_001153735.1
    XP_038960003.1
    XP_063139013.1
    XP_063139014.1
    XP_063139015.1
    XP_063139016.1
    XP_063139017.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160263.2 → NP_001153735.1  histo-blood group ABO system transferase 2

      See identical proteins and their annotated locations for NP_001153735.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q8CFC4
      UniProtKB/TrEMBL
      A6JTH9
      Related
      ENSRNOP00000091204.2, ENSRNOT00000099183.2
      Conserved Domains (1) summary
      pfam03414
      Location:47 → 334
      Glyco_transf_6; Glycosyltransferase family 6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      30560172..30604758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282943.1 → XP_063139013.1  histo-blood group ABO system transferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y5Y8
      Related
      ENSRNOP00000077138.2, ENSRNOT00000115517.2

    2. XM_063282945.1 → XP_063139015.1  histo-blood group ABO system transferase 2 isoform X2

    3. XM_063282946.1 → XP_063139016.1  histo-blood group ABO system transferase 2 isoform X2

    4. XM_039104075.2 → XP_038960003.1  histo-blood group ABO system transferase 2 isoform X2

      Conserved Domains (1) summary
      cl11394
      Location:1 → 212
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    5. XM_063282947.1 → XP_063139017.1  histo-blood group ABO system transferase 2 isoform X2

    6. XM_063282944.1 → XP_063139014.1  histo-blood group ABO system transferase 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFC4.1 GenPept UniProtKB/Swiss-Prot:Q8CFC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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