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    rho-4 rhomboid-4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32109, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rho-4provided by FlyBase
    Official Full Name
    rhomboid-4provided by FlyBase
    Primary source
    FLYBASE:FBgn0030318
    Locus tag
    Dmel_CG1697
    See related
    AllianceGenome:FB:FBgn0030318
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1697; Dmel\CG1697; DmRho4; rho 4; Rho-4; Rho-related [10C6]; rho4
    Summary
    Enables calcium ion binding activity and serine-type endopeptidase activity. Involved in epidermal growth factor receptor ligand maturation. Located in Golgi membrane and plasma membrane. Is expressed in adult head. Orthologous to human RHBDL1 (rhomboid like 1) and RHBDL3 (rhomboid like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rho-4 in Genome Data Viewer
    Location:
    10C10-10C10; 1-35 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11599838..11606288)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11493871..11500321)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Replication protein A3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion. Kreutzberger AJB, et al. Science, 2019 Feb 1. PMID 30705155, Free PMC Article
    2. Cytosolic extensions directly regulate a rhomboid protease by modulating substrate gating. Baker RP, et al. Nature, 2015 Jul 2. PMID 25970241, Free PMC Article
    3. Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics. Moin SM, et al. Elife, 2012 Nov 13. PMID 23150798, Free PMC Article
    4. brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling. Guichard A, et al. Dev Biol, 2000 Oct 15. PMID 11023685
    5. A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands. Urban S, et al. EMBO J, 2002 Aug 15. PMID 12169630, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 11605690-11606077 mobile_element_type = transposon:Tom1{}5976

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in epidermal growth factor receptor ligand maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rhomboid-4
    Names
    CG1697-PA
    CG1697-PB
    Rhomboid-4
    rho-4-PA
    rho-4-PB
    rhomboid 4
    NP_525084.1
    NP_727538.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11599838..11606288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080345.3 → NP_525084.1  rhomboid-4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525084.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYW6
      Related
      FBpp0073365
      Conserved Domains (3) summary
      cd00051
      Location:73 → 134
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl23634
      Location:57 → 197
      EFh_HEF; EF-hand, calcium binding motif, found in the hexa-EF hand proteins family
      pfam01694
      Location:226 → 374
      Rhomboid; Rhomboid family

    2. NM_167290.3 → NP_727538.1  rhomboid-4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727538.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYW6
      Related
      FBpp0073366
      Conserved Domains (3) summary
      cd00051
      Location:73 → 134
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl23634
      Location:57 → 197
      EFh_HEF; EF-hand, calcium binding motif, found in the hexa-EF hand proteins family
      pfam01694
      Location:226 → 374
      Rhomboid; Rhomboid family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYW6 Q9VYW6

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