scny scrawny [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: scnyprovided by FlyBase
Official Full Name: scrawnyprovided by FlyBase
Primary source: FLYBASE:FBgn0260936
Locus tag: Dmel_CG5505
See related: AllianceGenome:FB:FBgn0260936
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 2331; anon-WO0118547.247; CG5505; Dmel\CG5505; dUsp36; dUSP36; et; l(3)02331; mule; Q9VRP5; Scny; SP36/Scny; usp36; Usp36; USP36
Summary: Enables K63-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Involved in several processes, including germ-line stem cell population maintenance; negative regulation of defense response; and positive regulation of proteasomal protein catabolic process. Located in nucleolus. Is expressed in several structures, including adult brain cell body rind; adult fat body; germline stem cell; salivary gland; and synaptic neuropil domain. Used to study congenital heart disease and primary ovarian insufficiency. Orthologous to several human genes including USP36 (ubiquitin specific peptidase 36) and USP42 (ubiquitin specific peptidase 42). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 64E7-64E7; 3-15 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5769002..5776271)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5762102..5769371)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

specific inactivation in hemocytes renders susceptibility to L. monocytogenes infections
Title: The Drosophila deubiquitinating enzyme dUSP36 acts in the hemocytes for tolerance to Listeria monocytogenes infections.
USP36 controls selective autophagy activation in Drosophila and in human cells.
Title: The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins.
The study describes Drosophila ubiquitin protease USP36/Scny function in innate immunity. USP36 is notably required in the gut and prevents constitutive activation of NF-kappaB signal by hydrolysing K63 ubiquitin chains on the adaptator molecule IMD.
Title: The Drosophila ubiquitin-specific protease dUSP36/Scny targets IMD to prevent constitutive immune signaling.
study describes a Drosophila gene, scrawny (scny), encoding a ubiquitin-specific protease, which is required in germline, epithelial & intestinal stem cells; it deubiquitylates histone H2B and functions in gene silencing
Title: Drosophila stem cells share a common requirement for the histone H2B ubiquitin protease scrawny.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables K63-linked deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of antimicrobial peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein deubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	HDA more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: scrawny

Names: CG5505-PB; CG5505-PC; CG5505-PD; CG5505-PG; CG5505-PH; CG5505-PI; CG5505-PJ; emperor's thumb; lethal (3) 02331; mule; scny-PB; scny-PC; scny-PD; scny-PG; scny-PH; scny-PI; scny-PJ; ubiquitin C-terminal hydrolase 36; ubiquitin specific protease 36; ubiquitin-specific protease 36

NP_001246639.1

EC 3.4.19.12

NP_001246640.1

EC 3.4.19.12

NP_647986.3

EC 3.4.19.12

NP_729092.1

EC 3.4.19.12

NP_729093.2

EC 3.4.19.12

NP_729094.1

EC 3.4.19.12

NP_729095.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

5769002..5776271

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168132.3 → NP_729092.1 scrawny, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729092.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9NE30, Q7YTX7, Q86NM9, Q8IQ57, Q8IQ58, Q8IQ59, Q8IQ60, Q960Q4, Q9VRP5

Related

FBpp0076806

Conserved Domains (3) summary

pfam05279
Location:617 → 731

Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

cd02661
Location:171 → 477

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:172 → 477

UCH; Ubiquitin carboxyl-terminal hydrolase
NM_001259710.2 → NP_001246639.1 scrawny, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246639.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VRP5

Conserved Domains (3) summary

pfam05279
Location:617 → 731

Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

cd02661
Location:171 → 477

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:172 → 477

UCH; Ubiquitin carboxyl-terminal hydrolase
NM_001259711.2 → NP_001246640.1 scrawny, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246640.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VRP5

Conserved Domains (3) summary

pfam05279
Location:617 → 731

Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

cd02661
Location:171 → 477

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:172 → 477

UCH; Ubiquitin carboxyl-terminal hydrolase
NM_139729.3 → NP_647986.3 scrawny, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_647986.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VRP5

Conserved Domains (3) summary

pfam05279
Location:547 → 661

Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

cd02661
Location:101 → 407

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:102 → 407

UCH; Ubiquitin carboxyl-terminal hydrolase
NM_168135.2 → NP_729095.1 scrawny, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729095.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VRP5

Related

FBpp0076807

Conserved Domains (3) summary

pfam05279
Location:547 → 661

Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

cd02661
Location:101 → 407

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:102 → 407

UCH; Ubiquitin carboxyl-terminal hydrolase
NM_168134.2 → NP_729094.1 scrawny, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729094.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VRP5

Related

FBpp0076809

Conserved Domains (3) summary

pfam05279
Location:527 → 641

Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

cd02661
Location:81 → 387

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:82 → 387

UCH; Ubiquitin carboxyl-terminal hydrolase
NM_168133.2 → NP_729093.2 scrawny, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729093.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VRP5

Conserved Domains (3) summary

pfam05279
Location:527 → 641

Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region

cd02661
Location:81 → 387

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:82 → 387

UCH; Ubiquitin carboxyl-terminal hydrolase