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    Tengl2 Testis EndoG-Like 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318044, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tengl2provided by FlyBase
    Official Full Name
    Testis EndoG-Like 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0052463
    Locus tag
    Dmel_CG32463
    See related
    AllianceGenome:FB:FBgn0052463
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17006; CG32463; Dmel\CG32463
    Summary
    Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human ENDOG (endonuclease G). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tengl2 in Genome Data Viewer
    Location:
    22D5-22D5; 2-5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2238304..2239384, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2238304..2239384, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Secretory 24CD Neighboring gene antisense RNA:CR44115 Neighboring gene Testis EndoG-Like 3 Neighboring gene Testis EndoG-Like 1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42859

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Barriers to male transmission of mitochondrial DNA in sperm development. DeLuca SZ, et al. Dev Cell, 2012 Mar 13. PMID 22421049, Free PMC Article
    2. Molecular definitions of autophagy and related processes. Galluzzi L, et al. EMBO J, 2017 Jul 3. PMID 28596378, Free PMC Article
    3. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    testis EndoG-Like 2
    Names
    CG32463-PA
    Tengl2-PA
    NP_722779.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2238304..2239384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164466.2 → NP_722779.1  testis EndoG-Like 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722779.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0HDN6, Q8IPZ0
      Related
      FBpp0077485
      Conserved Domains (1) summary
      pfam01223
      Location:74 → 300
      Endonuclease_NS; DNA/RNA non-specific endonuclease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IPZ0 Q8IPZ0

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