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    Mrp5 Multidrug resistance protein 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42362, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrp5provided by FlyBase
    Official Full Name
    Multidrug resistance protein 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0038740
    Locus tag
    Dmel_CG4562
    See related
    AllianceGenome:FB:FBgn0038740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4562; CT14766; DmCG4562; Dmel\CG4562; Dme_CG4562; dMRP5
    Summary
    Enables ABC-type heme transporter activity. Involved in heme export. Located in plasma membrane. Is expressed in adult head and spermatozoon. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mrp5 in Genome Data Viewer
    Location:
    92B4-92B4; 3-67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19865417..19875678, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15691139..15701400, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Mitochondrial calcium uptake 3 Neighboring gene Inositol-requiring enzyme-1 Neighboring gene Mitochondrial rRNA methyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Activator-recruited cofactor subunit 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insecticide detoxification indicator strains as tools for enhancing chemical discovery screens. Shah S, et al. Pest Manag Sci, 2012 Jan. PMID 21681918
    2. The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family. Tarnay JN, et al. Insect Mol Biol, 2004 Oct. PMID 15373810
    3. Combgap contributes to recruitment of Polycomb group proteins in Drosophila. Ray P, et al. Proc Natl Acad Sci U S A, 2016 Apr 5. PMID 27001825, Free PMC Article
    4. Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. Mayer F, et al. J Neurosci, 2009 Mar 18. PMID 19295159, Free PMC Article
    5. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster. Wang Z, et al. BMC Biol, 2022 Jun 2. PMID 35655259, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type heme transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme export IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    multidrug resistance protein 5
    Names
    CG4562-PA
    CG4562-PB
    CG4562-PC
    CG4562-PD
    CG4562-PE
    Mrp5-PA
    Mrp5-PB
    Mrp5-PC
    Mrp5-PD
    Mrp5-PE
    NP_001097841.1
    NP_001262745.1
    NP_001262746.1
    NP_001262747.1
    NP_650838.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19865417..19875678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275816.1 → NP_001262745.1  multidrug resistance protein 5, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262745.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDT3
      Conserved Domains (4) summary
      cd03244
      Location:1074 → 1295
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:443 → 643
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:12 → 1300
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:799 → 1027
      ABC_membrane; ABC transporter transmembrane region

    2. NM_142581.2 → NP_650838.1  multidrug resistance protein 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650838.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDT3
      Related
      FBpp0083268
      Conserved Domains (4) summary
      cd03244
      Location:1074 → 1295
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:443 → 643
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:12 → 1300
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:799 → 1027
      ABC_membrane; ABC transporter transmembrane region

    3. NM_001275818.1 → NP_001262747.1  multidrug resistance protein 5, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262747.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGI0
      Conserved Domains (4) summary
      cd03244
      Location:1074 → 1295
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:443 → 643
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:12 → 1300
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:799 → 1027
      ABC_membrane; ABC transporter transmembrane region

    4. NM_001275817.1 → NP_001262746.1  multidrug resistance protein 5, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262746.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BI72
      Conserved Domains (3) summary
      cd03250
      Location:443 → 643
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      COG1132
      Location:92 → 663
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      cl00549
      Location:98 → 367
      ABC_membrane; ABC transporter transmembrane region

    5. NM_001104371.2 → NP_001097841.1  multidrug resistance protein 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097841.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BI72
      Conserved Domains (3) summary
      cd03250
      Location:443 → 643
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      COG1132
      Location:92 → 663
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      cl00549
      Location:98 → 367
      ABC_membrane; ABC transporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGI0 A0A0B4KGI0
    Q5BI72 Q5BI72
    Q9VDT3 Q9VDT3

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