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    Mov10 Mov10 RISC complex RNA helicase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36922, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mov10provided by FlyBase
    Official Full Name
    Mov10 RISC complex RNA helicaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034187
    Locus tag
    Dmel_CG6967
    See related
    AllianceGenome:FB:FBgn0034187
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6967; CT21565; Dmel\CG6967; dMOV10
    Summary
    Enables RISC complex binding activity and sequence-specific mRNA binding activity. Involved in positive regulation of miRNA-mediated gene silencing. Located in cytosol. Is expressed in germline cell; gonad; organism; and primordial germ cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mov10 in Genome Data Viewer
    Location:
    53F4-53F4; 2-81 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17062775..17066546)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12950280..12954051)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene fat-spondin Neighboring gene teflon Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene snoRNA:Orphan CD box 17 Neighboring gene Sphingosine-1-phosphate lyase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced Function of the Glutathione S-Transferase S1 Suppresses Behavioral Hyperexcitability in Drosophila Expressing Mutant Voltage-Gated Sodium Channels. Chen HL, et al. G3 (Bethesda), 2020 Apr 9. PMID 32054635, Free PMC Article
    2. Drosophila MOV10 regulates the termination of midgut regeneration. Takemura M, et al. Genetics, 2021 May 17. PMID 33693718, Free PMC Article
    3. Investigating the Evolution of Drosophila STING-Dependent Antiviral Innate Immunity by Multispecies Comparison of 2'3'-cGAMP Responses. Hédelin L, et al. Mol Biol Evol, 2024 Mar 1. PMID 38377349, Free PMC Article
    4. Development of fly tolerance to consuming a high-protein diet requires physiological, metabolic and transcriptional changes. Yurkevych IS, et al. Biogerontology, 2020 Oct. PMID 32468146
    5. C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Lee KH, et al. Cell, 2016 Oct 20. PMID 27768896, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila MOV10 regulates the termination of midgut regeneration.
      Title: Drosophila MOV10 regulates the termination of midgut regeneration.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-3' RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-3' RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RISC complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of miRNA-mediated gene silencing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Mov10 RISC complex RNA helicase
    Names
    CG6967-PC
    CG6967-PD
    Mov10-PC
    Mov10-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17062775..17066546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166214.3 → NP_725650.3  Mov10 RISC complex RNA helicase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725650.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAP7, Q8MRI1, Q9V7X9
      Conserved Domains (3) summary
      pfam13086
      Location:251 → 456
      AAA_11; AAA domain
      pfam13245
      Location:256 → 323
      AAA_19; Part of AAA domain
      cl22977
      Location:464 → 665
      UvrD_C_2; UvrD-like helicase C-terminal domain

    2. NM_137341.3 → NP_611185.3  Mov10 RISC complex RNA helicase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611185.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAP7, Q8MRI1, Q9V7X9
      Conserved Domains (3) summary
      pfam13086
      Location:251 → 456
      AAA_11; AAA domain
      pfam13245
      Location:256 → 323
      AAA_19; Part of AAA domain
      cl22977
      Location:464 → 665
      UvrD_C_2; UvrD-like helicase C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAP7 A1ZAP7
    Q8MRI1 Q8MRI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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