Sirup Starvation-upregulated protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sirupprovided by FlyBase
Official Full Name: Starvation-upregulated proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0031971
Locus tag: Dmel_CG7224
See related: AllianceGenome:FB:FBgn0031971
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey12; BcDNA:GH18422; CG7224; Dmel\CG7224; dSdhaf4; Sdhaf4
Summary: Enables enzyme activator activity. Involved in several processes, including cellular response to reactive oxygen species; mitochondrial respiratory chain complex II assembly; and positive regulation of succinate dehydrogenase activity. Predicted to be active in mitochondrion. Is expressed in several structures, including adult fat body; adult head; head epidermis primordium; somatic trunk mesoderm derivative; and trunk visceral muscle primordium. Used to study candidiasis. Orthologous to human SDHAF4 (succinate dehydrogenase complex assembly factor 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (7998869..7999676)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (7998869..7999676)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables enzyme activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular respiration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial respiratory chain complex II assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex II assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of succinate dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

Names: CG7224-PA; CG7224-PC; Sirup-PA; Sirup-PC; starvation-upregulated protein

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