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    CG40486 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355162, updated on 9-Dec-2024

    Summary

    Official Symbol
    CG40486provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263830
    Locus tag
    Dmel_CG40486
    See related
    AllianceGenome:FB:FBgn0263830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12466; Dmel\CG40486; FOHSDR
    Summary
    Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Is expressed in adult fat body. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See CG40486 in Genome Data Viewer
    Location:
    20F3-20F3; 1-66 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22958856..22960091, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (22360692..22361927, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene CTD nuclear envelope phosphatase 1 regulatory subunit 1 Neighboring gene long non-coding RNA:CR45502 Neighboring gene uncharacterized protein Neighboring gene stoned A Neighboring gene stoned B

    Genomic regions, transcripts, and products

    General gene information

    mobile_element

    • Loc: c22959359-22959290 mobile_element_type = transposon:INE-1{}3857

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity  
    enables 17-beta-ketosteroid reductase (NADPH) activity  
    enables 3-keto sterol reductase activity  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity  

    General protein information

    Preferred Names
    uncharacterized protein
    Names
    CG40486-PB
    CG40486-PC
    NP_001036311.2
    NP_001036312.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      22958856..22960091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042846.3NP_001036311.2  uncharacterized protein Dmel_CG40486, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036311.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5LJT3
      Conserved Domains (2) summary
      COG4221
      Location:1247
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
      cl21454
      Location:1242
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. NM_001042847.3NP_001036312.1  uncharacterized protein Dmel_CG40486, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036312.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5LJT3
      Conserved Domains (2) summary
      COG4221
      Location:1247
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
      cl21454
      Location:1242
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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