U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG6225 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41559, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG6225provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038072
    Locus tag
    Dmel_CG6225
    See related
    AllianceGenome:FB:FBgn0038072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6225
    Summary
    Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; larval glial cell; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to human XPNPEP2 (X-prolyl aminopeptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG6225 in Genome Data Viewer
    Location:
    87C3-87C3; 3-52 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12654577..12660860)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8480299..8486582)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46351 Neighboring gene Dpp target gene Neighboring gene long non-coding RNA:CR45586 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. CRISPR Gene Drive Efficiency and Resistance Rate Is Highly Heritable with No Common Genetic Loci of Large Effect. Champer J, et al. Genetics, 2019 May. PMID 30918006, Free PMC Article
    2. Comparison of embryonic expression within multigene families using the FlyExpress discovery platform reveals more spatial than temporal divergence. Konikoff CE, et al. Dev Dyn, 2012 Jan. PMID 21960044, Free PMC Article
    3. Genes underlying species differences in cuticular hydrocarbon production between Drosophila melanogaster and D. simulans. Ward HKE, et al. Genome, 2021 Feb. PMID 33211537
    4. MidExDB: a database of Drosophila CNS midline cell gene expression. Wheeler SR, et al. BMC Dev Biol, 2009 Nov 10. PMID 19903351, Free PMC Article
    5. Functional correlates of positional and gender-specific renal asymmetry in Drosophila. Chintapalli VR, et al. PLoS One, 2012. PMID 22496733, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG6225-PA
    CG6225-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12654577..12660860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104289.2 → NP_001097759.1  uncharacterized protein Dmel_CG6225, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097759.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VG44
      Conserved Domains (5) summary
      COG0006
      Location:213 → 589
      PepP; Xaa-Pro aminopeptidase [Amino acid transport and metabolism]
      cd01085
      Location:371 → 594
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:597 → 660
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:209 → 368
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:92 → 195
      Creatinase_N; Creatinase/Prolidase N-terminal domain

    2. NM_141964.3 → NP_650221.1  uncharacterized protein Dmel_CG6225, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650221.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VG44
      Related
      FBpp0082118
      Conserved Domains (5) summary
      COG0006
      Location:213 → 589
      PepP; Xaa-Pro aminopeptidase [Amino acid transport and metabolism]
      cd01085
      Location:371 → 594
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:597 → 660
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:209 → 368
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:92 → 195
      Creatinase_N; Creatinase/Prolidase N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VG44 Q9VG44

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools