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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853028, updated on 9-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000003359
    Locus tag
    YGR127W
    See related
    AllianceGenome:SGD:S000003359; FungiDB:YGR127W; VEuPathDB:YGR127W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in Golgi organization and protein secretion. Located in peroxisome. Human ortholog(s) of this gene implicated in TANGO2-related metabolic encephalopathy and arrythmias. Orthologous to human TANGO2 (transport and golgi organization 2 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (746798..747736)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Vsb1p Neighboring gene uncharacterized protein Neighboring gene Utp8p Neighboring gene Syf2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media. Lai LC, et al. Mol Cell Biol, 2005 May. PMID 15870279, Free PMC Article
    2. Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions. Yifrach E, et al. Mol Syst Biol, 2022 Sep. PMID 36164978, Free PMC Article
    3. The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis. Yap WS, et al. J Cell Sci, 2020 Nov 5. PMID 33033181, Free PMC Article
    4. Meiosis-specific cohesin component, Rec8, promotes the localization of Mps3 SUN domain protein on the nuclear envelope. Bommi JR, et al. Genes Cells, 2019 Jan. PMID 30417519
    5. A Genome-Wide Screen Reveals a Role for the HIR Histone Chaperone Complex in Preventing Mislocalization of Budding Yeast CENP-A. Ciftci-Yilmaz S, et al. Genetics, 2018 Sep. PMID 30012561, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_011643.1
    • Protein involved in heme trafficking to the nucleus; expression is regulated by Msn2p/Msn4p, indicating possible role in stress response; localizes to cytosol and peroxisomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      746798..747736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181256.1 → NP_011643.1  TPA: uncharacterized protein YGR127W [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011643.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUQ9, P53275
      UniProtKB/TrEMBL
      A6ZUE1, B3LIA1, C7GUG8, N1P424
      Conserved Domains (1) summary
      COG3332
      Location:1 → 309
      NRDE; Uncharacterized conserved protein, contains NRDE domain [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53275.1

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