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    Jon65Aiv Jonah 65Aiv [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38682, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jon65Aivprovided by FlyBase
    Official Full Name
    Jonah 65Aivprovided by FlyBase
    Primary source
    FLYBASE:FBgn0250815
    Locus tag
    Dmel_CG6467
    See related
    AllianceGenome:FB:FBgn0250815
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH23808; CG6467; Dmel\CG6467; End; Jon65; Jon65A; jon65aiv; jon65Aiv; SP117
    Summary
    Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. Is expressed in adult head; cuboidal/columnar epithelium; gastric caecum; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jon65Aiv in Genome Data Viewer
    Location:
    65A3-65A3; 3-16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6039155..6040135)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6032255..6033235)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43952 Neighboring gene uncharacterized protein Neighboring gene Jonah 65Aiii Neighboring gene Jonah 65Aii

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability. Vieira J, et al. PLoS One, 2012. PMID 22427812, Free PMC Article
    2. Expression of defense genes in Drosophila evolves under a different selective regime from expression of other genes. Wayne ML, et al. Evolution, 2011 Apr. PMID 21108635, Free PMC Article
    3. The detection of Jonah gene transcripts in Drosophila by in situ hybridization. Akam ME, et al. EMBO J, 1985 Jan. PMID 2410252, Free PMC Article
    4. Developmental and functional analysis of Jonah gene expression. Carlson JR, et al. Dev Biol, 1985 Apr. PMID 2416611
    5. Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila. González J, et al. PLoS Genet, 2010 Apr 8. PMID 20386746, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jonah 65Aiv
    Names
    BEST:GH23808
    CG6467-PA
    Jon65Aiv-PA
    Jonah65A-IV
    jonah 65A
    NP_648012.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6039155..6040135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139755.3 → NP_648012.1  jonah 65Aiv [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648012.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYB5, Q9VRS6
      Related
      FBpp0076748
      Conserved Domains (2) summary
      smart00020
      Location:37 → 265
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:38 → 268
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYB5 Q8SYB5
    Q9VRS6 Q9VRS6

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