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    Bap111 Brahma associated protein 111kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bap111provided by FlyBase
    Official Full Name
    Brahma associated protein 111kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030093
    Locus tag
    Dmel_CG7055
    See related
    AllianceGenome:FB:FBgn0030093
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.83; BAF57; BAP 111; bap111; BAP111; CG7055; clone 1.83; dalao; Dalao; Dmel\CG7055
    Summary
    Predicted to enable DNA binding activity and nuclear receptor binding activity. Involved in chromatin remodeling and positive regulation of DNA-templated transcription. Located in nucleus. Part of brahma complex. Is expressed in several structures, including CNS glial cell; anterior endoderm anlage; central brain primordium; ganglia; and midgut primordium. Used to study candidiasis. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 5; familial meningioma; and meningioma. Orthologous to human SMARCE1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bap111 in Genome Data Viewer
    Location:
    8C14-8C14; 1-26 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9149309..9151976)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9043342..9046009)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene frataxin Neighboring gene Histone H3.3B Neighboring gene Oligosaccharyltransferase 48kD subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular biology of HMGA proteins: hubs of nuclear function. Reeves R. Gene, 2001 Oct 17. PMID 11602345
    2. Mechanisms for ATP-dependent chromatin remodelling: farewell to the tuna-can octamer? Flaus A, et al. Curr Opin Genet Dev, 2004 Apr. PMID 15196463
    3. Protein complex-based analysis framework for high-throughput data sets. Vinayagam A, et al. Sci Signal, 2013 Feb 26. PMID 23443684, Free PMC Article
    4. The HMG-domain protein BAP111 is important for the function of the BRM chromatin-remodeling complex in vivo. Papoulas O, et al. Proc Natl Acad Sci U S A, 2001 May 8. PMID 11331758, Free PMC Article
    5. The Swi/Snf family nucleosome-remodeling complexes and transcriptional control. Sudarsanam P, et al. Trends Genet, 2000 Aug. PMID 10904263

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nuclear receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromatin remodeling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of brahma complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of brahma complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    brahma associated protein 111kD
    Names
    BRM-associated protein 111
    Bap111-PA
    CG7055-PA
    dalao

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9149309..9151976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132302.4 → NP_572530.1  brahma associated protein 111kD [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572530.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BIW6, Q9W384
      Related
      FBpp0071235
      Conserved Domains (1) summary
      cd01390
      Location:95 → 154
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BIW6 Q9BIW6
    Q9W384 Q9W384

    Gene LinkOut

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