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    Rcd5 Reduction in Cnn dots 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38478, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rcd5provided by FlyBase
    Official Full Name
    Reduction in Cnn dots 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0263832
    Locus tag
    Dmel_CG1135
    See related
    AllianceGenome:FB:FBgn0263832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1135; dMCRS1; dMCRS2; Dmel\CG1135; l(3)r0166; l(3)rG166; MCRS1; MCRS2; p78
    Summary
    Predicted to enable G-quadruplex RNA binding activity. Involved in centriole replication and positive regulation of transcription by RNA polymerase II. Located in nucleus and polytene chromosome interband. Part of NSL complex. Is expressed in organism. Orthologous to human MCRS1 (microspherule protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rcd5 in Genome Data Viewer
    Location:
    64A4-64A4; 3-10 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4040529..4042597)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4040529..4042597)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45042 Neighboring gene Gustatory receptor 64d Neighboring gene Gustatory receptor 64e Neighboring gene Gustatory receptor 64f Neighboring gene uncharacterized protein Neighboring gene Dpy-30-like 2 Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 305 member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The NSL complex regulates housekeeping genes in Drosophila. Lam KC, et al. PLoS Genet, 2012. PMID 22723752, Free PMC Article
    2. RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis. Pavlova GA, et al. PLoS Genet, 2019 Sep. PMID 31527906, Free PMC Article
    3. An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Meunier S, et al. Nat Commun, 2015 Aug 5. PMID 26243146, Free PMC Article
    4. Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element. Li L, et al. BMC Cell Biol, 2010 Jan 20. PMID 20089194, Free PMC Article
    5. The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise. Lam KC, et al. Genes Dev, 2019 Apr 1. PMID 30819819, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that dMCRS2 is required for loading of RNAP II complexes on the cyclin gene promoters.
      Title: Drosophila MCRS2 associates with RNA polymerase II complexes to regulate transcription.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G-quadruplex RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MLL1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NSL complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    reduction in Cnn dots 5
    Names
    CG1135-PA
    Rcd5-PA
    lethal (3) rG166

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4040529..4042597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139595.3 → NP_647852.1  reduction in Cnn dots 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647852.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZJ3
      Related
      FBpp0073058
      Conserved Domains (2) summary
      cd00060
      Location:465 → 559
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam13325
      Location:246 → 444
      MCRS_N; N-terminal region of micro-spherule protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZJ3 Q9VZJ3

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