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    loopin-1 loopin-1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    loopin-1provided by FlyBase
    Official Full Name
    loopin-1provided by FlyBase
    Primary source
    FLYBASE:FBgn0259795
    Locus tag
    Dmel_CG4750
    See related
    AllianceGenome:FB:FBgn0259795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.81; CG4750; Dmel\CG4750; FBgn0259795; kl3 lp-1; kl3lp1; loopin; S-LAP 6; S-Lap6
    Summary
    Predicted to enable manganese ion binding activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in adult head; adult heart; spermatogonium; spermatozoon; and testis. Orthologous to human LAP3 (leucine aminopeptidase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See loopin-1 in Genome Data Viewer
    Location:
    53C7-53C7; 2-80 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16534943..16537086)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12422448..12424591)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene knotted onions Neighboring gene Semaphorin 2a Neighboring gene Syntrophin-like 2 Neighboring gene Dopamine transporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conservation of lampbrush-like loops in drosophilids. Piergentili R. BMC Cell Biol, 2007 Aug 14. PMID 17697358, Free PMC Article
    2. Chromosome-specific maturation of the epigenome in the Drosophila male germline. Anderson JT, et al. Elife, 2023 Nov 30. PMID 38032818, Free PMC Article
    3. Cell-type-specific interacting proteins collaborate to regulate the timing of Cyclin B protein expression in male meiotic prophase. Baker CC, et al. Development, 2023 Nov 15. PMID 37882771, Free PMC Article
    4. Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm. Dorus S, et al. BMC Genomics, 2011 Apr 5. PMID 21466698, Free PMC Article
    5. Sperm-Leucylaminopeptidases are required for male fertility as structural components of mitochondrial paracrystalline material in Drosophila melanogaster sperm. Laurinyecz B, et al. PLoS Genet, 2019 Feb. PMID 30802236, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables metalloaminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables metalloaminopeptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in major mitochondrial derivative ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    loopin-1
    Names
    CG4750-PA
    CG4750-PC
    Sperm-LeucylAminoPeptidase 6
    kl-3 loop protein-1
    loopin-1-PA
    loopin-1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16534943..16537086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103868.2 → NP_001097338.1  loopin-1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097338.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2S9
      Conserved Domains (2) summary
      PRK00913
      Location:43 → 519
      PRK00913; multifunctional aminopeptidase A; Provisional
      cd00433
      Location:41 → 518
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

    2. NM_137290.4 → NP_611134.1  loopin-1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611134.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2S9
      Related
      FBpp0086239
      Conserved Domains (2) summary
      PRK00913
      Location:43 → 519
      PRK00913; multifunctional aminopeptidase A; Provisional
      cd00433
      Location:41 → 518
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K2S9 Q7K2S9

    Gene LinkOut

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