U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mthl13 methuselah-like 13 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246395, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mthl13provided by FlyBase
    Official Full Name
    methuselah-like 13provided by FlyBase
    Primary source
    FLYBASE:FBgn0050018
    Locus tag
    Dmel_CG30018
    See related
    AllianceGenome:FB:FBgn0050018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30018; Dmel\CG30018; Mthl13
    Summary
    Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryonic/larval lymph gland. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See mthl13 in Genome Data Viewer
    Location:
    47B13-47B13; 2-63 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10791459..10793109)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6678964..6680614)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44300 Neighboring gene long non-coding RNA:CR44301 Neighboring gene windei Neighboring gene uncharacterized protein Neighboring gene Nop10 ribonucleoprotein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress. Sung EJ, et al. Proc Natl Acad Sci U S A, 2017 Dec 26. PMID 29229844, Free PMC Article
    2. Massive parallel expansions of Methuselah/Methuselah-like receptors in schizophoran Diptera. Friedrich M, et al. J Exp Zool B Mol Dev Evol, 2018 Sep. PMID 30058118
    3. Gene Ages, Nomenclatures, and Functional Diversification of the Methuselah/Methuselah-Like GPCR Family in Drosophila and Tribolium. Friedrich M, et al. J Exp Zool B Mol Dev Evol, 2016 Dec. PMID 28074535
    4. Methuselah/Methuselah-like G protein-coupled receptors constitute an ancient metazoan gene family. de Mendoza A, et al. Sci Rep, 2016 Feb 26. PMID 26915348, Free PMC Article
    5. The Drosophila melanogaster methuselah gene: a novel gene with ancient functions. Araújo AR, et al. PLoS One, 2013. PMID 23696853, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    methuselah-like 13
    Names
    CG30018-PD
    mthl13-PD

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10791459..10793109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176145.3 → NP_788325.2  methuselah-like 13 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788325.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D4G7D6, V9H0I1
      Conserved Domains (1) summary
      cl11637
      Location:49 → 158
      Mth_Ecto; The ectodomain of Methuselah (Mth); Mth mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage; The protein affected by this mutation is related to G ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    V9H0I1 V9H0I1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools