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    Cyp6v1 Cytochrome P450 6v1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33056, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp6v1provided by FlyBase
    Official Full Name
    Cytochrome P450 6v1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031126
    Locus tag
    Dmel_CG1829
    See related
    AllianceGenome:FB:FBgn0031126
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    6v1; CG1829; Dmel\CG1829
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Predicted to be involved in insecticide catabolic process and response to DDT. Is expressed in adult head; gonad; organism; and ring gland. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp6v1 in Genome Data Viewer
    Location:
    19E1-19E1; 1-65 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20657122..20661425)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20528149..20532452)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Runt related A Neighboring gene antisense RNA:CR45466 Neighboring gene uncharacterized protein Neighboring gene hydra

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation. Schroeder MD, et al. Development, 2011 Jul. PMID 21693522, Free PMC Article
    2. Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation. Meiklejohn CD, et al. PLoS Biol, 2011 Aug. PMID 21857805, Free PMC Article
    3. Large clusters of co-expressed genes in the Drosophila genome. Boutanaev AM, et al. Nature, 2002 Dec 12. PMID 12478293
    4. CORECLUST: identification of the conserved CRM grammar together with prediction of gene regulation. Nikulova AA, et al. Nucleic Acids Res, 2012 Jul. PMID 22422836, Free PMC Article
    5. Comparative CYP-omic analysis between the DDT-susceptible and -resistant Drosophila melanogaster strains 91-C and 91-R. Seong KM, et al. Pest Manag Sci, 2018 Nov. PMID 29656515

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in insecticide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to DDT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 6v1
    Names
    CG1829-PA
    CG1829-PB
    CG1829-PC
    Cyp6v1-PA
    Cyp6v1-PB
    Cyp6v1-PC
    cytochrome P450
    NP_001285499.1
    NP_001285500.1
    NP_608403.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20657122..20661425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298570.1 → NP_001285499.1  cytochrome P450 6v1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285499.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9UNF2, Q9VRB3
      UniProtKB/TrEMBL
      X2JGA6
      Conserved Domains (1) summary
      cl12078
      Location:59 → 517
      p450; Cytochrome P450

    2. NM_134559.3 → NP_608403.1  cytochrome P450 6v1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608403.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9UNF2, Q9VRB3
      UniProtKB/TrEMBL
      X2JGA6
      Related
      FBpp0076968
      Conserved Domains (1) summary
      cl12078
      Location:59 → 517
      p450; Cytochrome P450

    3. NM_001298571.1 → NP_001285500.1  cytochrome P450 6v1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285500.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9UNF2, Q9VRB3
      UniProtKB/TrEMBL
      X2JGA6
      Conserved Domains (1) summary
      cl12078
      Location:59 → 517
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRB3.1 Q9VRB3
    X2JGA6 X2JGA6

    Gene LinkOut

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