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    Tsp86D Tetraspanin 86D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41310, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp86Dprovided by FlyBase
    Official Full Name
    Tetraspanin 86Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037848
    Locus tag
    Dmel_CG4591
    See related
    AllianceGenome:FB:FBgn0037848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4591; Dm.Tsp86D; Dmel\CG4591; tsp86D
    Summary
    Involved in intracellular protein transport and positive regulation of Notch signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TSPAN33 (tetraspanin 33). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp86D in Genome Data Viewer
    Location:
    86C7-86C7; 3-50 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10868708..10870555)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6694430..6696277)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Selenoprotein R Neighboring gene Formaldehyde dehydrogenase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SelR reverses Mical-mediated oxidation of actin to regulate F-actin dynamics. Hung RJ, et al. Nat Cell Biol, 2013 Dec. PMID 24212093, Free PMC Article
    2. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion. Seigneuret M, et al. J Biol Chem, 2001 Oct 26. PMID 11483611
    3. RNA interference screen to identify genes required for Drosophila embryonic nervous system development. Koizumi K, et al. Proc Natl Acad Sci U S A, 2007 Mar 27. PMID 17376868, Free PMC Article
    4. Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc. González-Méndez L, et al. EMBO J, 2020 Jun 2. PMID 32311148, Free PMC Article
    5. An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity. Xu C, et al. Proc Natl Acad Sci U S A, 2020 Jan 7. PMID 31852821, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 86D
    Names
    CG4591-PA
    CG4591-PB
    CG4591-PC
    Tetraspanin86D
    Tsp86D-PA
    Tsp86D-PB
    Tsp86D-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10868708..10870555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079585.5 → NP_524309.1  tetraspanin 86D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524309.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGV3
      Related
      FBpp0081765
      Conserved Domains (2) summary
      cd03158
      Location:132 → 255
      penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:30 → 283
      Tetraspannin; Tetraspanin family

    2. NM_001275539.1 → NP_001262468.1  tetraspanin 86D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262468.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFQ5
      Conserved Domains (2) summary
      cd03158
      Location:132 → 255
      penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:51 → 283
      Tetraspannin; Tetraspanin family

    3. NM_001260108.2 → NP_001247037.1  tetraspanin 86D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247037.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGV3
      Conserved Domains (2) summary
      cd03158
      Location:132 → 255
      penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:30 → 283
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFQ5 A0A0B4KFQ5
    Q9VGV3 Q9VGV3

    Gene LinkOut

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