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    CG5823 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42105, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5823provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038515
    Locus tag
    Dmel_CG5823
    See related
    AllianceGenome:FB:FBgn0038515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5823
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in ERAD pathway and protein polyubiquitination. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and nucleus. Is expressed in adult head and organism. Orthologous to human UBE2J2 (ubiquitin conjugating enzyme E2 J2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5823 in Genome Data Viewer
    Location:
    90B3-90B3; 3-61 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17532325..17534587, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13358047..13360309, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Down syndrome cell adhesion molecule 3 Neighboring gene long non-coding RNA:CR44349 Neighboring gene lethal (3) 07882 Neighboring gene Pyrroline-5-carboxylate reductase-like 2 Neighboring gene Splicing factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Septin 4, the drosophila ortholog of human CDCrel-1, accumulates in parkin mutant brains and is functionally related to the Nedd4 E3 ubiquitin ligase. Muñoz-Soriano V, et al. J Mol Neurosci, 2012 Sep. PMID 22562816
    2. A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium. Shao W, et al. PLoS One, 2010 Apr 1. PMID 20368978, Free PMC Article
    3. Drosophila melanogaster males respond differently at the behavioural and genome-wide levels to Drosophila melanogaster and Drosophila simulans females. Ellis LL, et al. J Evol Biol, 2009 Nov. PMID 19765174
    4. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article
    5. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5823-PA
    CG5823-PB
    NP_001262669.1
    NP_650631.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17532325..17534587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275740.1 → NP_001262669.1  uncharacterized protein Dmel_CG5823, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262669.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEJ4
      Conserved Domains (1) summary
      cd00195
      Location:16 → 129
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_142374.3 → NP_650631.1  uncharacterized protein Dmel_CG5823, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650631.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEJ4
      Related
      FBpp0082929
      Conserved Domains (1) summary
      cd00195
      Location:16 → 129
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEJ4 Q9VEJ4

    Gene LinkOut

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