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    TpnC4 Troponin C isoform 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35498, updated on 27-Dec-2024

    Summary

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    Official Symbol
    TpnC4provided by FlyBase
    Official Full Name
    Troponin C isoform 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0033027
    Locus tag
    Dmel_CG12408
    See related
    AllianceGenome:FB:FBgn0033027
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH03361; CG12408; Dmel\CG12408; DmTnC4; DmTpnC41F; DmTpnCIIIb; TnC; tnC4; Tnc4; TnC4; TNC41F6; TpnC IIIb; tpnc4; TPnC4; TpnC41F; TpnCIIIb
    Summary
    Predicted to enable calcium ion binding activity. Involved in flight. Predicted to be active in centrosome and cytoplasm. Is expressed in adult head; indirect flight muscle cell; and organism. Orthologous to human CALML6 (calmodulin like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TpnC4 in Genome Data Viewer
    Location:
    41F2-41F3; 2-55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5503437..5507866, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1390942..1395371, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene straw Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 50 member B3 Neighboring gene uncharacterized protein Neighboring gene Fission, mitochondrial 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The roles of troponin C isoforms in the mechanical function of Drosophila indirect flight muscle. Eldred CC, et al. J Muscle Res Cell Motil, 2014 Aug. PMID 25134799, Free PMC Article
    2. Neural control and precision of flight muscle activation in Drosophila. Lehmann FO, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2017 Jan. PMID 27942807, Free PMC Article
    3. Functional redundancy and nonredundancy between two Troponin C isoforms in Drosophila adult muscles. Chechenova MB, et al. Mol Biol Cell, 2017 Mar 15. PMID 28077621, Free PMC Article
    4. Roles of the troponin isoforms during indirect flight muscle development in Drosophila. Singh SH, et al. J Genet, 2014 Aug. PMID 25189233
    5. Expression patterns of the whole troponin C gene repertoire during Drosophila development. Herranz R, et al. Gene Expr Patterns, 2004 Mar. PMID 15161098

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c5504119-5503736 mobile_element_type = transposon:INE-1{}4260
    • Loc: c5504555-5504509 mobile_element_type = transposon:INE-1{}4263
    • Loc: c5507237-5507100 mobile_element_type = transposon:INE-1{}4264

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in flight IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    troponin C isoform 4
    Names
    CG12408-PA
    CG12408-PB
    TpnC4-PA
    TpnC4-PB
    troponin C
    troponin C 41F
    troponin C4
    troponin-C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5503437..5507866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169584.2 → NP_001163055.1  troponin C isoform 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K860, Q8SZM6
      Conserved Domains (2) summary
      PTZ00184
      Location:1 → 152
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:90 → 152
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. NM_136329.3 → NP_610173.2  troponin C isoform 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610173.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K860, Q8SZM6
      Related
      FBpp0085411
      Conserved Domains (2) summary
      PTZ00184
      Location:1 → 152
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:90 → 152
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K860 Q7K860
    Q8SZM6 Q8SZM6

    Gene LinkOut

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