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    rgn regeneration [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40368, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rgnprovided by FlyBase
    Official Full Name
    regenerationprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261258
    Locus tag
    Dmel_CG6014
    See related
    AllianceGenome:FB:FBgn0261258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH11973; CG6014; Dmel\CG6014; l(3)00534; RGN
    Summary
    Predicted to enable carbohydrate binding activity. Involved in tissue regeneration. Predicted to be active in endosome; trans-Golgi network; and trans-Golgi network transport vesicle. Is expressed in adult heart and prothoracic leg disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rgn in Genome Data Viewer
    Location:
    78C9-78D1; 3-47 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21382501..21424416)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21375601..21417516)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45953 Neighboring gene long non-coding RNA:CR45954 Neighboring gene spermatocyte arrest Neighboring gene barricade Neighboring gene uncharacterized protein Neighboring gene Adult enhancer factor 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rgn gene is required for gut cell homeostasis after ingestion of sodium dodecyl sulfate in Drosophila. Pan J, et al. Gene, 2014 Oct 1. PMID 25064488
    2. E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner. Pereira J, et al. Cell Commun Signal, 2024 Feb 27. PMID 38414029, Free PMC Article
    3. Three genes control the timing, the site and the size of blastema formation in Drosophila. McClure KD, et al. Dev Biol, 2008 Jul 1. PMID 18485344, Free PMC Article
    4. The transcription factor FoxK participates with Nup98 to regulate antiviral gene expression. Panda D, et al. mBio, 2015 Apr 7. PMID 25852164, Free PMC Article
    5. NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila. Lee C, et al. Mol Cell Biol, 2008 May. PMID 18332113, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner.
      Title: E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner.
    2. Study provides evidence that rgn gene is essential for gut cell homeostasis following damage in Drosophila.
      Title: Rgn gene is required for gut cell homeostasis after ingestion of sodium dodecyl sulfate in Drosophila.
    3. Study identified three genes, regeneration or rgn (CG6014), augmenter of liver regeneration (alr) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration.
      Title: Three genes control the timing, the site and the size of blastema formation in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbohydrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    regeneration
    Names
    CG6014-PA
    CG6014-PB
    CG6014-PC
    CG6014-PD
    lethal (3) 00534
    rgn-PA
    rgn-PB
    rgn-PC
    rgn-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21382501..21424416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141055.4 → NP_649312.1  regeneration, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649312.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP39, Q9Y102
      Related
      FBpp0078002
      Conserved Domains (3) summary
      cd00037
      Location:74 → 192
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      pfam13868
      Location:413 → 748
      TPH; Trichohyalin-plectin-homology domain
      cl11266
      Location:387 → 468
      EssA; WXG100 protein secretion system (Wss), protein EssA

    2. NM_001275226.1 → NP_001262155.1  regeneration, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262155.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFV8
      Conserved Domains (4) summary
      cd00037
      Location:74 → 200
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      pfam13868
      Location:421 → 756
      TPH; Trichohyalin-plectin-homology domain
      cd16269
      Location:483 → 494
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:414 → 508
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. NM_001259937.2 → NP_001246866.1  regeneration, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246866.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFV8
      Conserved Domains (4) summary
      cd00037
      Location:74 → 200
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      pfam13868
      Location:421 → 756
      TPH; Trichohyalin-plectin-homology domain
      cd16269
      Location:483 → 494
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:414 → 508
      GBP_C; Guanylate-binding protein, C-terminal domain

    4. NM_001275227.1 → NP_001262156.1  regeneration, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262156.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP39, Q9Y102
      Conserved Domains (3) summary
      cd00037
      Location:74 → 192
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      pfam13868
      Location:413 → 748
      TPH; Trichohyalin-plectin-homology domain
      cl11266
      Location:387 → 468
      EssA; WXG100 protein secretion system (Wss), protein EssA
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFV8 M9PFV8
    Q9Y102 Q9Y102

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