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    CG8407 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36303, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8407provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033687
    Locus tag
    Dmel_CG8407
    See related
    AllianceGenome:FB:FBgn0033687
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8407
    Summary
    Predicted to be involved in microtubule-based process. Predicted to be part of dynein complex. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to human DNAL4 (dynein axonemal light chain 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8407 in Genome Data Viewer
    Location:
    48E3-48E3; 2-66 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12153071..12154263)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8040576..8041768)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing, class 4, member 4 Neighboring gene Organic solute carrier partner 1 Neighboring gene Hen1 methyltransferase Neighboring gene back seat driver Neighboring gene pre-mRNA processing factor 8 Neighboring gene small Cajal body-specific RNA : PsiU2-55 Neighboring gene mir-988 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Krüppel-Like Factor Dar1 Determines Multipolar Neuron Morphology. Wang X, et al. J Neurosci, 2015 Oct 21. PMID 26490864, Free PMC Article
    2. Genome-wide identification of neuronal activity-regulated genes in Drosophila. Chen X, et al. Elife, 2016 Dec 9. PMID 27936378, Free PMC Article
    3. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP. Zur Lage P, et al. J Cell Biol, 2018 Jul 2. PMID 29743191, Free PMC Article
    4. Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Avidor-Reiss T, et al. Cell, 2004 May 14. PMID 15137945
    5. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8407-PA
    CG8407-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12153071..12154263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169653.2 → NP_001163124.1  uncharacterized protein Dmel_CG8407, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163124.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8T9, L0CQY5
      Conserved Domains (1) summary
      pfam01221
      Location:18 → 102
      Dynein_light; Dynein light chain type 1

    2. NM_136890.3 → NP_610734.1  uncharacterized protein Dmel_CG8407, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610734.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8T9, L0CQY5
      Related
      FBpp0087093
      Conserved Domains (1) summary
      pfam01221
      Location:18 → 102
      Dynein_light; Dynein light chain type 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8T9 A1Z8T9

    Gene LinkOut

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