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    tant tantalus [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tantprovided by FlyBase
    Official Full Name
    tantalusprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028980
    Locus tag
    Dmel_CG6586
    See related
    AllianceGenome:FB:FBgn0028980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6586; Dmel\CG6586; tan; Tan
    Summary
    Involved in sensory organ development. Located in cytoplasm and nucleus. Is expressed in several structures, including dorsal pharyngeal muscle primordium; eye disc morphogenetic furrow; larval muscle cell; larval muscle system; and somatic mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tant in Genome Data Viewer
    Location:
    65A4-65A4; 3-16 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6055136..6057002)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6048236..6050102)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Jonah 65Aii Neighboring gene Jonah 65Ai Neighboring gene long non-coding RNA:CR45441 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Little effect of the tan locus on pigmentation in female hybrids between Drosophila santomea and D. melanogaster. Matute DR, et al. Cell, 2009 Dec 11. PMID 20005810, Free PMC Article
    2. A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system. Romero-Calderón R, et al. PLoS Genet, 2008 Nov. PMID 18989452, Free PMC Article
    3. The functional organisation of glia in the adult brain of Drosophila and other insects. Edwards TN, et al. Prog Neurobiol, 2010 Apr. PMID 20109517, Free PMC Article
    4. Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila. Shao L, et al. Proc Natl Acad Sci U S A, 2011 Nov 15. PMID 22049342, Free PMC Article
    5. Pigmentation and behavior: potential association through pleiotropic genes in Drosophila. Takahashi A. Genes Genet Syst, 2013. PMID 24025245

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In contrast to NBAD-synthase, Tan is expressed constitutively in epidermis and does not respond directly to microbial challenge. The study shows the novel localization of tan in embryo central neural system and in different regions of adult brain.
      Title: Constitutive expression and enzymatic activity of Tan protein in brain and epidermis of Ceratitis capitata and of Drosophila melanogaster wild-type and tan mutants.
    2. Hybridization tests using D. melanogaster deficiencies that include tan show no evidence that this locus is involved in the lighter pigmentation of D. santomea females; rather, the pigmentation difference appears to involve at least 4 other loci.
      Title: Little effect of the tan locus on pigmentation in female hybrids between Drosophila santomea and D. melanogaster.
    3. Tan expression is confined to the photoreceptor cells R1-R8.
      Title: Drosophila photoreceptors express cysteine peptidase tan.
    4. The previously observed ability of TAN to move between the cytoplasm and nucleus, and to associate with DNA, provides a potential mechanism for TAN to respond to N signalling.
      Title: tantalus, a potential link between Notch signalling and chromatin-remodelling complexes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tantalus
    Names
    CG6586-PA
    CG6586-PB
    tant-PA
    tant-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6055136..6057002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274531.1 → NP_001261460.1  tantalus, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261460.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T0D4, Q9NHW6, Q9VRT0
      UniProtKB/TrEMBL
      M9PEG8
      Conserved Domains (1) summary
      pfam15386
      Location:121 → 174
      Tantalus; Drosophila Tantalus-like

    2. NM_080043.3 → NP_524782.2  tantalus, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524782.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T0D4, Q9NHW6, Q9VRT0
      UniProtKB/TrEMBL
      M9PEG8
      Related
      FBpp0076751
      Conserved Domains (1) summary
      pfam15386
      Location:121 → 174
      Tantalus; Drosophila Tantalus-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEG8 M9PEG8
    Q8T0D4.1 Q8T0D4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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