U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Jon65Ai Jonah 65Ai [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38685, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Jon65Aiprovided by FlyBase
    Official Full Name
    Jonah 65Aiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035667
    Locus tag
    Dmel_CG10475
    See related
    AllianceGenome:FB:FBgn0035667
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10475; CT29408; Dmel\CG10475; Jon65; Jon65A; SP145
    Summary
    Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Jon65Ai in Genome Data Viewer
    Location:
    65A4-65A4; 3-16 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6053493..6054443, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6046593..6047543, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Jonah 65Aiii Neighboring gene Jonah 65Aii Neighboring gene tantalus Neighboring gene long non-coding RNA:CR45441

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structure-function analysis of Lactiplantibacillus plantarum DltE reveals D-alanylated lipoteichoic acids as direct cues supporting Drosophila juvenile growth. Nikolopoulos N, et al. Elife, 2023 Apr 12. PMID 37042660, Free PMC Article
    2. Drosophila C virus systemic infection leads to intestinal obstruction. Chtarbanova S, et al. J Virol, 2014 Dec. PMID 25253354, Free PMC Article
    3. Pathogen Virulence Impedes Mutualist-Mediated Enhancement of Host Juvenile Growth via Inhibition of Protein Digestion. Erkosar B, et al. Cell Host Microbe, 2015 Oct 14. PMID 26439865, Free PMC Article
    4. D-Alanylation of teichoic acids contributes to Lactobacillus plantarum-mediated Drosophila growth during chronic undernutrition. Matos RC, et al. Nat Microbiol, 2017 Dec. PMID 28993620, Free PMC Article
    5. Developmental and functional analysis of Jonah gene expression. Carlson JR, et al. Dev Biol, 1985 Apr. PMID 2416611

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    jonah 65Ai
    Names
    CG10475-PA
    CG10475-PB
    Jon65Ai-PA
    Jon65Ai-PB
    jonah 65A
    NP_001286951.1
    NP_648015.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6053493..6054443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300022.1 → NP_001286951.1  jonah 65Ai, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286951.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRS9
      Conserved Domains (2) summary
      smart00020
      Location:37 → 254
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:41 → 257
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_139758.2 → NP_648015.1  jonah 65Ai, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648015.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRS9
      Related
      FBpp0076775
      Conserved Domains (2) summary
      smart00020
      Location:37 → 254
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:41 → 257
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRS9 Q9VRS9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools