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    Slob Slowpoke binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34038, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slobprovided by FlyBase
    Official Full Name
    Slowpoke binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264087
    Locus tag
    Dmel_CG43756
    See related
    AllianceGenome:FB:FBgn0264087
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13792; CG43756; CG6772; Dmel\CG43756; slob; SLOB
    Old locus tag
    Dmel_CG13792; Dmel_CG6772
    Summary
    Enables protein kinase activity. Involved in neuromuscular synaptic transmission; regulation of membrane potential; and response to starvation. Is expressed in several structures, including efferent neurons; neuromuscular junction; photoreceptor neurons; synaptic neuropil domain; and synaptic neuropil subdomain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Slob in Genome Data Viewer
    Location:
    28B4-28C1; 2-28 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7642005..7675078, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7642005..7675078, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44799 Neighboring gene long non-coding RNA:CR44800 Neighboring gene Myosin 28B1 Neighboring gene long non-coding RNA:CR44148 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The slowpoke channel binding protein Slob from Drosophila melanogaster exhibits regulatable protein kinase activity. Zeng H, et al. Neurosci Lett, 2004 Jul 15. PMID 15234468
    2. Age-Related Unstructured Spike Patterns and Molecular Localization in Drosophila Circadian Neurons. Nguyen DL, et al. Front Physiol, 2022. PMID 35356078, Free PMC Article
    3. Slob, a Slowpoke channel-binding protein, modulates synaptic transmission. Ma H, et al. J Gen Physiol, 2011 Feb. PMID 21282401, Free PMC Article
    4. Dynamic neuronal instability generates synaptic plasticity and behavior: Insights from Drosophila sleep. Tabuchi M. Neurosci Res, 2024 Jan. PMID 37385545, Free PMC Article
    5. Monomeric 14-3-3 protein is sufficient to modulate the activity of the Drosophila slowpoke calcium-dependent potassium channel. Zhou Y, et al. J Biol Chem, 2003 Mar 21. PMID 12529354

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    slowpoke binding protein
    Names
    CG43756-PA
    CG43756-PB
    CG43756-PC
    CG43756-PD
    CG43756-PE
    CG43756-PF
    CG43756-PG
    CG43756-PH
    CG43756-PI
    CG43756-PJ
    CG43756-PK
    SLO-binding protein
    SLOWPOKE-binding protein
    Slob-PA
    Slob-PB
    Slob-PC
    Slob-PD
    Slob-PE
    Slob-PF
    Slob-PG
    Slob-PH
    Slob-PI
    Slob-PJ
    Slob-PK
    giant slob
    slowpoke channel binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7642005..7675078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135287.2 → NP_609131.2  slowpoke binding protein, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609131.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLZ5
      Conserved Domains (1) summary
      cd00180
      Location:130 → 298
      PKc; Catalytic domain of Protein Kinases

    2. NM_001273283.1 → NP_001260212.1  slowpoke binding protein, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260212.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB66
      Conserved Domains (1) summary
      cd00180
      Location:286 → 481
      PKc; Catalytic domain of Protein Kinases

    3. NM_001273282.1 → NP_001260211.1  slowpoke binding protein, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260211.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF34
      Conserved Domains (1) summary
      cd00180
      Location:219 → 387
      PKc; Catalytic domain of Protein Kinases

    4. NM_001201784.2 → NP_001188713.1  slowpoke binding protein, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188713.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z388, M9MRE3
      Conserved Domains (1) summary
      cd00180
      Location:163 → 331
      PKc; Catalytic domain of Protein Kinases

    5. NM_001201782.1 → NP_001188711.1  slowpoke binding protein, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188711.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRL0
      Conserved Domains (1) summary
      cd00180
      Location:286 → 454
      PKc; Catalytic domain of Protein Kinases

    6. NM_164756.3 → NP_723292.1  slowpoke binding protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723292.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z388
      Conserved Domains (1) summary
      cd00180
      Location:342 → 510
      PKc; Catalytic domain of Protein Kinases

    7. NM_001201783.1 → NP_001188712.1  slowpoke binding protein, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z388, M9MRG6
      Conserved Domains (1) summary
      cd00180
      Location:163 → 331
      PKc; Catalytic domain of Protein Kinases

    8. NM_001038792.1 → NP_001033881.1  slowpoke binding protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033881.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z388, M9MRD7
      Conserved Domains (1) summary
      cd00180
      Location:219 → 387
      PKc; Catalytic domain of Protein Kinases

    9. NM_058001.3 → NP_477349.1  slowpoke binding protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477349.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61564, Q5BIJ6, Q8IPH9, Q95SL3, Q9VLZ4
      UniProtKB/TrEMBL
      A4V0D4, D1Z388
      Conserved Domains (1) summary
      cd00180
      Location:219 → 387
      PKc; Catalytic domain of Protein Kinases

    10. NM_164757.2 → NP_723293.1  slowpoke binding protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723293.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61564, Q5BIJ6, Q8IPH9, Q95SL3, Q9VLZ4
      UniProtKB/TrEMBL
      A4V0D4, D1Z388
      Conserved Domains (1) summary
      cd00180
      Location:219 → 387
      PKc; Catalytic domain of Protein Kinases

    11. NM_001201781.1 → NP_001188710.1  slowpoke binding protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188710.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z388, M9MRD7
      Conserved Domains (1) summary
      cd00180
      Location:219 → 387
      PKc; Catalytic domain of Protein Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V0D4 A4V0D4
    M9MRD7 M9MRD7
    M9MRE3 M9MRE3
    M9MRG6 M9MRG6
    M9MRL0 M9MRL0
    M9PB66 M9PB66
    M9PF34 M9PF34
    Q8IPH9.2 Q8IPH9
    Q9VLZ5 Q9VLZ5

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