Coq8 Coenzyme Q8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Coq8provided by FlyBase
Official Full Name: Coenzyme Q8provided by FlyBase
Primary source: FLYBASE:FBgn0052649
Locus tag: Dmel_CG32649
See related: AllianceGenome:FB:FBgn0052649
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Adck4; CG32649; CG4410; dADCK3/4; dcoq8; Dmel\CG32649
Summary: Predicted to enable ATP hydrolysis activity; lipid binding activity; and protein kinase activity. Predicted to be involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Is expressed in several structures, including adult head; embryonic brain; embryonic/larval midgut primordium; foregut primordium; and gut section. Used to study coenzyme Q10 deficiency disease; nephrotic syndrome; nephrotic syndrome type 9; and primary coenzyme Q10 deficiency 4. Human ortholog(s) of this gene implicated in nephrotic syndrome type 9 and primary coenzyme Q10 deficiency 4. Orthologous to human COQ8A (coenzyme Q8A) and COQ8B (coenzyme Q8B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (12898768..12901114, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (12792801..12795147, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

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