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    CG4836 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42387, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4836provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0270925
    Locus tag
    Dmel_CG4836
    See related
    AllianceGenome:FB:FBgn0270925
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.105; anon-WO0140519.33; bs15h04.y1; bs36e10.y1; Dmel\CG4836; DM_7300579; SODH-1; Srd
    Summary
    Predicted to enable L-iditol 2-dehydrogenase (NAD+) activity. Predicted to be involved in sorbitol catabolic process. Is expressed in adult head and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4836 in Genome Data Viewer
    Location:
    92C1-92C1; 3-67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20013872..20018248)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15839594..15843970)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 25 Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class L Neighboring gene phagocyte signaling impaired

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Do candidate genes mediating conspecific sperm precedence affect sperm competitive ability within species? A test case in Drosophila. Civetta A, et al. G3 (Bethesda), 2014 Jul 16. PMID 25031180, Free PMC Article
    2. Population- and sex-biased gene expression in the excretion organs of Drosophila melanogaster. Huylmans AK, et al. G3 (Bethesda), 2014 Sep 22. PMID 25246242, Free PMC Article
    3. Loss of Drosophila Clueless differentially affects the mitochondrial proteome compared to loss of Sod2 and Pink1. Sen A, et al. Front Physiol, 2022. PMID 36388112, Free PMC Article
    4. Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Avidor-Reiss T, et al. Cell, 2004 May 14. PMID 15137945
    5. Conserved properties of Drosophila and human spermatozoal mRNA repertoires. Fischer BE, et al. Proc Biol Sci, 2012 Jul 7. PMID 22378807, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-iditol 2-dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in sorbitol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4836-PA
    CG4836-PB
    CG4836-PC
    CG4836-PD
    CG4836-PE
    L-iditol 2-dehydrogenase
    sorbitol dehydrogenase
    NP_001138084.1
    NP_001138085.1
    NP_650856.2
    NP_732476.2
    NP_732477.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20013872..20018248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142599.3 → NP_650856.2  uncharacterized protein Dmel_CG4836, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650856.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDQ9
      Related
      FBpp0083237
      Conserved Domains (2) summary
      COG1063
      Location:886 → 1210
      Tdh; Threonine dehydrogenase or related Zn-dependent dehydrogenase [Amino acid transport and metabolism, General function prediction only]
      cl16912
      Location:881 → 1211
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    2. NM_169883.2 → NP_732477.2  uncharacterized protein Dmel_CG4836, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732477.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0R969, Q8IN61, Q8MRL0
      Related
      FBpp0083235

    3. NM_169882.2 → NP_732476.2  uncharacterized protein Dmel_CG4836, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732476.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IN62
      Related
      FBpp0083236
      Conserved Domains (2) summary
      COG1063
      Location:883 → 1207
      Tdh; Threonine dehydrogenase or related Zn-dependent dehydrogenase [Amino acid transport and metabolism, General function prediction only]
      cl16912
      Location:878 → 1208
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    4. NM_001144613.2 → NP_001138085.1  uncharacterized protein Dmel_CG4836, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138085.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0M7
      Conserved Domains (2) summary
      COG1063
      Location:893 → 1217
      Tdh; Threonine dehydrogenase or related Zn-dependent dehydrogenase [Amino acid transport and metabolism, General function prediction only]
      cl16912
      Location:888 → 1218
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    5. NM_001144612.2 → NP_001138084.1  uncharacterized protein Dmel_CG4836, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138084.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0M8, E0R969
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0M7 B7Z0M7
    B7Z0M8 B7Z0M8
    Q8IN62 Q8IN62
    Q8MRL0 Q8MRL0
    Q9VDQ9 Q9VDQ9

    Gene LinkOut

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