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    eEF1gamma eukaryotic translation elongation factor 1 gamma [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44791, updated on 17-Dec-2024

    Summary

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    Official Symbol
    eEF1gammaprovided by FlyBase
    Official Full Name
    eukaryotic translation elongation factor 1 gammaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029176
    Locus tag
    Dmel_CG11901
    See related
    AllianceGenome:FB:FBgn0029176
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11901; Dmel\CG11901; EF1 gamma; Ef1Bggr; Ef1gamma; EF1gamma; Ef1y
    Summary
    Enables microtubule binding activity. Involved in regulation of organelle transport along microtubule. Located in cytoplasm and nucleus. Is expressed in adult head; adult heart; embryonic/larval midgut; larval ventral nerve cord; and organism. Orthologous to human EEF1G (eukaryotic translation elongation factor 1 gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eEF1gamma in Genome Data Viewer
    Location:
    99A1-99A1; 3-98 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29220172..29222109)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25045894..25047831)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA::CR31044 Neighboring gene mir-279 stem loop Neighboring gene mir-996 stem loop Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene Bromodomain containing 8 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein kinase Darkener of apricot and its substrate EF1γ regulate organelle transport along microtubules. Serpinskaya AS, et al. J Cell Sci, 2014 Jan 1. PMID 24163433, Free PMC Article
    2. Rapid adaptive radiation and host plant conservation in the Hawaiian picture wing Drosophila (Diptera: Drosophilidae). Magnacca KN, et al. Mol Phylogenet Evol, 2015 Nov. PMID 26151218
    3. Role of BicDR in bristle shaft construction and support of BicD functions. Jejina A, et al. J Cell Sci, 2024 Jan 15. PMID 38264934, Free PMC Article
    4. Drosophila PS2 and PS3 integrins play distinct roles in retinal photoreceptors-glia interactions. Tavares L, et al. Glia, 2015 Jul. PMID 25731761
    5. Drosophila translational elongation factor-1gamma is modified in response to DOA kinase activity and is essential for cellular viability. Fan Y, et al. Genetics, 2010 Jan. PMID 19841092, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DOA protein and its substrate EF-1gamma regulate organelle transport along microtubules.
      Title: Protein kinase Darkener of apricot and its substrate EF1γ regulate organelle transport along microtubules.
    2. EF1gamma functions in vital cellular processes in addition to translational elongation and is a LAMMER kinase substrate in vivo.
      Title: Drosophila translational elongation factor-1gamma is modified in response to DOA kinase activity and is essential for cellular viability.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of organelle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation elongation factor 1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation elongation factor 1 gamma
    Names
    CG11901-PA
    CG11901-PB
    CG11901-PC
    Ef1gamma
    eEF1gamma-PA
    eEF1gamma-PB
    eEF1gamma-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29220172..29222109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202379.2 → NP_001189308.1  eukaryotic translation elongation factor 1 gamma, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189308.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4JD11, A4V3K9, Q6NL63, Q8IGT6, Q9NJH0, Q9NJH1, Q9VAM7
      Conserved Domains (4) summary
      cd03181
      Location:90 → 209
      GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
      COG0625
      Location:5 → 187
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03044
      Location:4 → 79
      GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...
      pfam00647
      Location:271 → 376
      EF1G; Elongation factor 1 gamma, conserved domain

    2. NM_170401.3 → NP_733280.1  eukaryotic translation elongation factor 1 gamma, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733280.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4JD11, A4V3K9, Q6NL63, Q8IGT6, Q9NJH0, Q9NJH1, Q9VAM7
      Related
      FBpp0084761
      Conserved Domains (4) summary
      cd03181
      Location:90 → 209
      GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
      COG0625
      Location:5 → 187
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03044
      Location:4 → 79
      GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...
      pfam00647
      Location:271 → 376
      EF1G; Elongation factor 1 gamma, conserved domain

    3. NM_143743.3 → NP_652000.1  eukaryotic translation elongation factor 1 gamma, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652000.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4JD11, A4V3K9, Q6NL63, Q8IGT6, Q9NJH0, Q9NJH1, Q9VAM7
      Related
      FBpp0084762
      Conserved Domains (4) summary
      cd03181
      Location:90 → 209
      GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
      COG0625
      Location:5 → 187
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03044
      Location:4 → 79
      GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...
      pfam00647
      Location:271 → 376
      EF1G; Elongation factor 1 gamma, conserved domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JD11 A0A0B4JD11
    Q9NJH0.2 Q9NJH0

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