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    yip7 yippee interacting protein 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38680, updated on 9-Dec-2024

    Summary

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    Official Symbol
    yip7provided by FlyBase
    Official Full Name
    yippee interacting protein 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0040060
    Locus tag
    Dmel_CG6457
    See related
    AllianceGenome:FB:FBgn0040060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6457; Dmel\CG6457; mac; MAC; SP116; SPH116; Yip7
    Summary
    Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. Is expressed in adult head and embryonic midgut chamber. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See yip7 in Genome Data Viewer
    Location:
    65A3-65A3; 3-16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6035216..6036175)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6028316..6029275)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene PVR adaptor protein Neighboring gene alpha Karyopherin-4 Neighboring gene long non-coding RNA:CR43952 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In Drosophila Hemolymph, Serine Proteases Are the Major Gelatinases and Caseinases. Gatti JL, et al. Insects, 2024 Mar 28. PMID 38667364, Free PMC Article
    2. A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes. Bozler J, et al. PLoS Genet, 2017 Oct. PMID 29084214, Free PMC Article
    3. Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation. Kambris Z, et al. Curr Biol, 2006 Apr 18. PMID 16631589
    4. Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3. Chen WY, et al. EMBO Rep, 2015 Apr. PMID 25666827, Free PMC Article
    5. A survey of ovary-, testis-, and soma-biased gene expression in Drosophila melanogaster adults. Parisi M, et al. Genome Biol, 2004. PMID 15186491, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    yippee interacting protein 7
    Names
    CG6457-PA
    machete
    yip7-PA
    NP_523944.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6035216..6036175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079220.2 → NP_523944.1  yippee interacting protein 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523944.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYN3, Q9VRS4
      Related
      FBpp0076746
      Conserved Domains (2) summary
      smart00020
      Location:39 → 264
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:40 → 267
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JYN3 Q7JYN3
    Q9NIU1 Q9NIU1
    Q9VRS4 Q9VRS4

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