U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rsph3 Radial spoke head protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38751, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rsph3provided by FlyBase
    Official Full Name
    Radial spoke head protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0052392
    Locus tag
    Dmel_CG32392
    See related
    AllianceGenome:FB:FBgn0052392
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10099; CG14912; CG32392; Dmel\CG32392; dRSPH3; rsp3
    Summary
    Involved in axoneme assembly and sperm individualization. Located in cytosol; nucleus; and sperm flagellum. Is expressed in Bolwig organ; chordotonal neurons; embryonic head sensory system; spermatogonium; and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 32. Orthologous to human RSPH3 (radial spoke head 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rsph3 in Genome Data Viewer
    Location:
    65C4-65C4; 3-17 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6756629..6763246, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6749729..6756346, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene veloren Neighboring gene SBDS ribosome maturation factor Neighboring gene Ist1 Neighboring gene long non-coding RNA:CR45759 Neighboring gene ventral veins lacking

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. RSBP15 interacts with and stabilizes dRSPH3 during sperm axoneme assembly in Drosophila. Wang Y, et al. J Genet Genomics, 2019 Jun 20. PMID 31281031
    2. Combover interacts with the axonemal component Rsp3 and is required for Drosophila sperm individualization. Steinhauer J, et al. Development, 2019 Sep 2. PMID 31391193, Free PMC Article
    3. An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development. Sotillos S, et al. Dev Biol, 2010 Apr 15. PMID 20171201, Free PMC Article
    4. Flying through the drosophila cytoskeletal genome. Goldstein LS, et al. J Cell Biol, 2000 Jul 24. PMID 10908588, Free PMC Article
    5. Genetic programs activated by proneural proteins in the developing Drosophila PNS. Reeves N, et al. Dev Cell, 2005 Mar. PMID 15737936

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RSBP15 interacts with and stabilizes dRSPH3 during sperm axoneme assembly
      Title: RSBP15 interacts with and stabilizes dRSPH3 during sperm axoneme assembly in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    radial spoke head protein 3
    Names
    CG32392-PA
    CG32392-PB
    Rsph3-PA
    Rsph3-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6756629..6763246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168180.2 → NP_729190.1  radial spoke head protein 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729190.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T476, Q9VRY8
      Related
      FBpp0076656
      Conserved Domains (1) summary
      pfam06098
      Location:78 → 356
      Radial_spoke_3; Radial spoke protein 3

    2. NM_139802.3 → NP_648059.1  radial spoke head protein 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648059.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRY7
      Related
      FBpp0076657
      Conserved Domains (1) summary
      pfam06098
      Location:326 → 604
      Radial_spoke_3; Radial spoke protein 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T476 Q8T476
    Q9VRY7 Q9VRY7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools