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    barc barricade [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40369, updated on 9-Dec-2024

    Summary

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    Official Symbol
    barcprovided by FlyBase
    Official Full Name
    barricadeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037081
    Locus tag
    Dmel_CG6049
    See related
    AllianceGenome:FB:FBgn0037081
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Barc; cg6049; CG6049; cus2; Dmel\CG6049; Tat-SF1
    Summary
    Enables U2 snRNP binding activity. Involved in positive regulation of RNA splicing and regulation of neurogenesis. Predicted to be part of U2 snRNP and U2-type spliceosomal complex. Is expressed in organism. Orthologous to human HTATSF1 (HIV-1 Tat specific factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See barc in Genome Data Viewer
    Location:
    78D1-78D2; 3-47 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21420388..21433134, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21413488..21426234, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene regeneration Neighboring gene long non-coding RNA:CR45954 Neighboring gene spermatocyte arrest Neighboring gene uncharacterized protein Neighboring gene Adult enhancer factor 1 Neighboring gene uncharacterized protein Neighboring gene Alkaline phosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. U2AF homology motifs: protein recognition in the RRM world. Kielkopf CL, et al. Genes Dev, 2004 Jul 1. PMID 15231733, Free PMC Article
    2. The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. Abramczuk MK, et al. Development, 2017 Nov 1. PMID 28935704
    3. Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression. Andersen DS, et al. J Biol Chem, 2008 Nov 7. PMID 18765666, Free PMC Article
    4. Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis. Kelsom C, et al. Cell Biosci, 2012 Nov 14. PMID 23151376, Free PMC Article
    5. Drosophila PSI controls circadian period and the phase of circadian behavior under temperature cycle via tim splicing. Foley LE, et al. Elife, 2019 Nov 8. PMID 31702555, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U2 snRNP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    barricade
    Names
    CG6049-PA
    CG6049-PC
    barc-PA
    barc-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21420388..21433134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168902.3 → NP_730629.1  barricade, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730629.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K204
      Related
      FBpp0078053
      Conserved Domains (2) summary
      cd12281
      Location:283 → 373
      RRM1_TatSF1_like; RNA recognition motif 1 in HIV Tat-specific factor 1 (Tat-SF1) and similar proteins
      cd12282
      Location:414 → 504
      RRM2_TatSF1_like; RNA recognition motif 2 in HIV Tat-specific factor 1 (Tat-SF1) and similar proteins

    2. NM_141056.4 → NP_649313.1  barricade, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649313.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K204
      Related
      FBpp0078054
      Conserved Domains (2) summary
      cd12281
      Location:283 → 373
      RRM1_TatSF1_like; RNA recognition motif 1 in HIV Tat-specific factor 1 (Tat-SF1) and similar proteins
      cd12282
      Location:414 → 504
      RRM2_TatSF1_like; RNA recognition motif 2 in HIV Tat-specific factor 1 (Tat-SF1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K204 Q7K204

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