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    PFK27 6-phosphofructo-2-kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853984, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PFK27
    Official Full Name
    6-phosphofructo-2-kinase
    Primary source
    SGD:S000005496
    Locus tag
    YOL136C
    See related
    AllianceGenome:SGD:S000005496; FungiDB:YOL136C; VEuPathDB:YOL136C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Involved in fructose 2,6-bisphosphate metabolic process and regulation of glycolytic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PFK27 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (67561..68754, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rtc1p Neighboring gene Bsc6p Neighboring gene mediator complex subunit MED7 Neighboring gene SCF ubiquitin ligase complex subunit HRT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of a second gene encoding 5-phosphofructo-2-kinase in yeast, and characterization of mutant strains without fructose-2,6-bisphosphate. Boles E, et al. Mol Microbiol, 1996 Apr. PMID 8861205
    2. Kinetics of 6-phosphofructo-2-kinase from Saccharomyces cerevisiae: inhibition of the enzyme by ATP. Bedri A, et al. Biomed Biochim Acta, 1989. PMID 2529854
    3. Activation of yeast 6-phosphofructo-2-kinase by protein kinase and phosphate. Yamashoji S, et al. FEBS Lett, 1984 Dec 10. PMID 6096166
    4. Mutation of monofunctional 6-phosphofructo-2-kinase in yeast to bifunctional 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase. Kretschmer M, et al. Biochemistry, 1993 Oct 19. PMID 8218176
    5. Sequence analysis of a 12 801 bp fragment of the left arm of yeast chromosome XV containing a putative 6-phosphofructo-2-kinase gene, a gene for a possible glycophospholipid-anchored surface protein and six other open reading frames. Aldea M, et al. Yeast, 1996 Sep. PMID 8896270

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pfk27 is a metabolic targets of Skp1-Cul1-F-box (SCF) ubiquitin ligase.
      Title: A proteomic screen reveals SCFGrr1 targets that regulate the glycolytic-gluconeogenic switch.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 6-phosphofructo-2-kinase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    6-phosphofructo-2-kinase
    NP_014505.1
    • 6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      67561..68754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183390.1 → NP_014505.1  TPA: 6-phosphofructo-2-kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014505.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1T3, Q12471
      UniProtKB/TrEMBL
      A6ZN76, B3LIT1, B5VRC5, C7GV11, C8ZHI1, G2WMA2, N1NWZ7
      Conserved Domains (1) summary
      pfam01591
      Location:84 → 324
      6PF2K; 6-phosphofructo-2-kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12471.1

    Gene LinkOut

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