Socs3 suppressor of cytokine signaling 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Socs3provided by MGI
Official Full Name: suppressor of cytokine signaling 3provided by MGI
Primary source: MGI:MGI:1201791
See related: Ensembl:ENSMUSG00000053113 AllianceGenome:MGI:1201791
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cis3; Ef10; Ssi3; Cish3; EF-10; SSI-3
Summary: Enables miRNA binding activity and phosphotyrosine residue binding activity. Involved in cellular response to interleukin-17. Acts upstream of or within several processes, including branching involved in labyrinthine layer morphogenesis; cellular response to leukemia inhibitory factor; and negative regulation of insulin receptor signaling pathway. Predicted to be located in cytosol. Predicted to be active in cytoplasmic side of plasma membrane. Is expressed in several structures, including extraembryonic component; liver; placenta; retina; and spleen. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SOCS3 (suppressor of cytokine signaling 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 19.8), duodenum adult (RPKM 16.3) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 82.96 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (117856905..117860192, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (117966079..117970336, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suppression of SOCS3 expression in macrophage cells: Potential application in diabetic wound healing.
Title: Suppression of SOCS3 expression in macrophage cells: Potential application in diabetic wound healing.
SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages.
Title: SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages.
Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy.
Title: Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy.
Transcription Factor ATF3 Mediating SOCS3 Expression Aggravates Renal Ischemia-Reperfusion Injury by Activating Mitophagy.
Title: Transcription Factor ATF3 Mediating SOCS3 Expression Aggravates Renal Ischemia-Reperfusion Injury by Activating Mitophagy.
Neuropathic pain development following nerve injury is mediated by SOX11-ARID1A-SOCS3 transcriptional regulation in the spinal cord.
Title: Neuropathic pain development following nerve injury is mediated by SOX11-ARID1A-SOCS3 transcriptional regulation in the spinal cord.
MiR-9 promotes G-MDSC recruitment and tumor proliferation by targeting SOCS3 in breast cancer.
Title: MiR-9 promotes G-MDSC recruitment and tumor proliferation by targeting SOCS3 in breast cancer.
Inhibition of SOCS3 signaling in the nucleus tractus solitarii and retrotrapezoid nucleus alleviates hypoventilation in diet-induced obese male mice.
Title: Inhibition of SOCS3 signaling in the nucleus tractus solitarii and retrotrapezoid nucleus alleviates hypoventilation in diet-induced obese male mice.
Neuronal Ptpn1 and Socs3 deletion improves metabolism but not anovulation in a mouse polycystic ovary syndrome model.
Title: Neuronal Ptpn1 and Socs3 deletion improves metabolism but not anovulation in a mouse polycystic ovary syndrome model.
SOCS3 inhibits the mesenchymal stromal cell secretory factor SDF-1-mediated improvement of islet function in non-obese diabetic mice.
Title: SOCS3 inhibits the mesenchymal stromal cell secretory factor SDF-1-mediated improvement of islet function in non-obese diabetic mice.
Socs3 expression in myeloid cells modulates the pathogenesis of dextran sulfate sodium (DSS)-induced colitis.
Title: Socs3 expression in myeloid cells modulates the pathogenesis of dextran sulfate sodium (DSS)-induced colitis.

Submit: New GeneRIF Correction See all GeneRIFs (326)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Socs3 (e-PCR), detects polymorphism
- UniSTS:532244

PMC303338P2 (e-PCR)
- UniSTS:272498

PMC148819P1 (e-PCR)
- UniSTS:271014

PMC148819P2 (e-PCR)
- UniSTS:271015

PMC22025P1 (e-PCR)
- UniSTS:272091

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables miRNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphotyrosine residue binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-17	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within placenta blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of signal transduction	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: suppressor of cytokine signaling 3

Names: CIS-3; E2a-Pbx1 target gene in fibroblasts 10; STAT-induced STAT inhibitor 3; cytokine inducible SH2-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007707.3 → NP_031733.1 suppressor of cytokine signaling 3

See identical proteins and their annotated locations for NP_031733.1

Status: VALIDATED

Source sequence(s)

AK152514, AL591433, BC052031

Consensus CDS

CCDS25697.1

UniProtKB/Swiss-Prot

O35718, P97803, Q3U7X5

UniProtKB/TrEMBL

Q3U9J8

Related

ENSMUSP00000059129.4, ENSMUST00000054002.4

Conserved Domains (2) summary

cd10384
Location:35 → 135

SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03737
Location:184 → 225

SOCS_SOCS3; SOCS (suppressors of cytokine signaling) box of SOCS3-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS3, like CIS1 and SOCS1, is involved in the ...