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    wbpZ glycosyltransferase WbpZ [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878012, updated on 24-Aug-2024

    Summary

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    Gene symbol
    wbpZ
    Gene description
    glycosyltransferase WbpZ
    Locus tag
    PA5447
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (6135968..6137113, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene coenzyme A transferase Neighboring gene hypothetical protein Neighboring gene glycosyltransferase WbpY Neighboring gene glycosyltransferase WbpX Neighboring gene ABC transporter Neighboring gene LPS efflux transporter membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A convenient synthesis of GDP-D-rhamnose: the donor substrate for D-rhamnosyltransferase WbpZ from Pseudomonas aeruginosa PAO1. Wang S, et al. Bioorg Med Chem Lett, 2013 Jun 15. PMID 23664878
    2. Biosynthesis of the Common Polysaccharide Antigen of Pseudomonas aeruginosa PAO1: Characterization and Role of GDP-D-Rhamnose:GlcNAc/GalNAc-Diphosphate-Lipid α1,3-D-Rhamnosyltransferase WbpZ. Wang S, et al. J Bacteriol, 2015 Jun 15. PMID 25845842, Free PMC Article
    3. Three rhamnosyltransferases responsible for assembly of the A-band D-rhamnan polysaccharide in Pseudomonas aeruginosa: a fourth transferase, WbpL, is required for the initiation of both A-band and B-band lipopolysaccharide synthesis. Rocchetta HL, et al. Mol Microbiol, 1998 Jun. PMID 9680202
    4. The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics. Cantarel BL, et al. Nucleic Acids Res, 2009 Jan. PMID 18838391, Free PMC Article
    5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This is the first characterization of a D-rhamnosyltransferase and shows that it is essential in Pseudomonas aeruginosa for the synthesis of the common polysaccharide antigen.
      Title: Biosynthesis of the Common Polysaccharide Antigen of Pseudomonas aeruginosa PAO1: Characterization and Role of GDP-D-Rhamnose:GlcNAc/GalNAc-Diphosphate-Lipid α1,3-D-Rhamnosyltransferase WbpZ.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables glycosyltransferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables rhamnose binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within O antigen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipopolysaccharide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycosyltransferase WbpZ
    NP_254134.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      6135968..6137113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_254134.1 glycosyltransferase WbpZ [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_254134.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9HTC0
      Conserved Domains (1) summary
      cd03795
      Location:2 → 356
      GT4_WfcD-like; Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HTC0.1

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