Gss glutathione synthetase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gssprovided by RGD
Official Full Name: glutathione synthetaseprovided by RGD
Primary source: RGD:2752
See related: EnsemblRapid:ENSRNOG00000018964 AllianceGenome:RGD:2752
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including anion binding activity; glutathione synthase activity; and identical protein binding activity. Involved in several processes, including glutathione biosynthetic process; response to amino acid; and response to tumor necrosis factor. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; glutathione synthetase deficiency of erythrocytes; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 738.1), Liver (RPKM 172.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (164508005..164538343, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (144047849..144078197, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (151076254..151106557, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

role of AP-1 in induction by tert-butylhydroquinone
Title: Role of AP-1 in the coordinate induction of rat glutamate-cysteine ligase and glutathione synthetase by tert-butylhydroquinone.

Submit: New GeneRIF Correction

General gene information

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Markers

D3Got112 (e-PCR)
- UniSTS:114200

Gss (e-PCR), detects polymorphism
- UniSTS:506956

RH127607 (e-PCR)
- UniSTS:210917

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables glutathione binding	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione binding	IDA Inferred from Direct Assay more info	PubMed
enables glutathione binding	IEA Inferred from Electronic Annotation more info
enables glutathione binding	ISO Inferred from Sequence Orthology more info
enables glutathione binding	ISS Inferred from Sequence or Structural Similarity more info
enables glutathione synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione synthase activity	IEA Inferred from Electronic Annotation more info
enables glutathione synthase activity	ISO Inferred from Sequence Orthology more info
enables glycine binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables peptide binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in glutathione biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cadmium ion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glutathione synthetase

Names: GSH synthetase; GSH-S; glutathione synthase

NP_037094.1

EC 6.3.2.3

XP_038960301.1

EC 6.3.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012962.1 → NP_037094.1 glutathione synthetase

See identical proteins and their annotated locations for NP_037094.1

Status: PROVISIONAL

Source sequence(s)

L38615

UniProtKB/Swiss-Prot

P46413

UniProtKB/TrEMBL

A0A8I6AYD3, A6KI44

Related

ENSRNOP00000025657.2, ENSRNOT00000025657.4

Conserved Domains (1) summary

cd00228
Location:6 → 474

eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

164508005..164538343 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104373.2 → XP_038960301.1 glutathione synthetase isoform X1

UniProtKB/TrEMBL

A0A8I6AYD3, A6KI45

Related

ENSRNOP00000107930.1, ENSRNOT00000170884.1

Conserved Domains (1) summary

cd00228
Location:1 → 405

eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.