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    ZNF207 zinc finger protein 207 [ Homo sapiens (human) ]

    Gene ID: 7756, updated on 9-Dec-2024

    Summary

    Official Symbol
    ZNF207provided by HGNC
    Official Full Name
    zinc finger protein 207provided by HGNC
    Primary source
    HGNC:HGNC:12998
    See related
    Ensembl:ENSG00000010244 MIM:603428; AllianceGenome:HGNC:12998
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BuGZ; hBuGZ
    Summary
    Enables microtubule binding activity. Involved in mitotic spindle assembly checkpoint signaling; nuclear chromosome segregation; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matrix. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 30.2), lymph node (RPKM 22.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF207 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (32350157..32381885)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (33295928..33327660)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (30677176..30708904)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene rhomboid like 3 Neighboring gene uncharacterized LOC124903980 Neighboring gene chromosome 17 open reading frame 75 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:30668222-30668404 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:30668873-30669759 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:30673436-30673617 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:30679433-30679942 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:30681259-30681760 Neighboring gene MPRA-validated peak2801 silencer Neighboring gene oocyte secreted protein 1 pseudogene 2 Neighboring gene microRNA 632 Neighboring gene nudix hydrolase 15 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:30771309-30771924 Neighboring gene proteasome 26S subunit, non-ATPase 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp761N202

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule bundle formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in spindle matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    BUB3-interacting and GLEBS motif-containing protein ZNF207

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032293.3NP_001027464.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform b

      See identical proteins and their annotated locations for NP_001027464.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 3. It encodes isoform b, which is shorter than isoform c.
      Source sequence(s)
      AC005899, AI308956, BC002372
      Consensus CDS
      CCDS32614.1
      UniProtKB/TrEMBL
      Q59G94
      Related
      ENSP00000378168.2, ENST00000394673.6
      Conserved Domains (3) summary
      sd00020
      Location:1334
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam06003
      Location:405440
      SMN; Survival motor neuron protein (SMN)
      cd20908
      Location:1090
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    2. NM_001098507.2NP_001091977.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform c

      See identical proteins and their annotated locations for NP_001091977.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AC005899, AI308956, AK226172, BC002372
      Consensus CDS
      CCDS42294.1
      UniProtKB/TrEMBL
      Q59G94
      Related
      ENSP00000378165.4, ENST00000394670.9
      Conserved Domains (3) summary
      sd00017
      Location:1332
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam06003
      Location:436471
      SMN; Survival motor neuron protein (SMN)
      cd20908
      Location:1090
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
    3. NM_003457.4NP_003448.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform a

      See identical proteins and their annotated locations for NP_003448.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an in-frame exon in the coding region, compared to variant 3. It encodes isoform a, which is shorter than isoform c.
      Source sequence(s)
      AC005899, AF046001, AI308956, BC002372
      Consensus CDS
      CCDS11271.1
      UniProtKB/Swiss-Prot
      A8K6Y6, E1P660, E1P661, E1P662, O43670, Q53XS9, Q96HW5, Q9BUQ7
      UniProtKB/TrEMBL
      Q59G94
      Related
      ENSP00000322777.6, ENST00000321233.10
      Conserved Domains (3) summary
      PHA03247
      Location:224436
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:1332
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:1090
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      32350157..32381885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      33295928..33327660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)