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    ZFAND6 zinc finger AN1-type containing 6 [ Homo sapiens (human) ]

    Gene ID: 54469, updated on 3-Dec-2024

    Summary

    Official Symbol
    ZFAND6provided by HGNC
    Official Full Name
    zinc finger AN1-type containing 6provided by HGNC
    Primary source
    HGNC:HGNC:30164
    See related
    Ensembl:ENSG00000086666 MIM:610183; AllianceGenome:HGNC:30164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AWP1; ZA20D3; ZFAND5B
    Summary
    Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in cellular response to tumor necrosis factor; negative regulation of apoptotic process; and regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 50.8), thyroid (RPKM 41.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZFAND6 in Genome Data Viewer
    Location:
    15q25.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (80058951..80138393)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (77923092..78001808)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (80352018..80430735)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9937 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:80262962-80264161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9938 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9940 Neighboring gene ribonucleotide reductase regulatory subunit M2 pseudogene Neighboring gene BCL2 related protein A1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:80293949-80294721 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:80295257-80296456 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9942 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:80320394-80320775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:80324347-80325092 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:80325837-80326580 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:80325093-80325836 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:80332051-80332550 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:80351696-80352024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:80404705-80405431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6731 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr15:80452567-80453210 and GRCh37_chr15:80453211-80453853 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:80460174-80460674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:80478509-80479009 Neighboring gene fumarylacetoacetate hydrolase Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41453 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41475 Neighboring gene cortexin domain containing 1 Neighboring gene NANOG hESC enhancer GRCh37_chr15:80534358-80534901

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to tumor necrosis factor IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein targeting to peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein targeting to peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    AN1-type zinc finger protein 6
    Names
    protein associated with PRK1
    zinc finger, A20 domain containing 3
    zinc finger, AN1-type domain 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242911.2NP_001229840.1  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_001229840.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
      Source sequence(s)
      AC092701, AL136598, AW571396, DB050060
      Consensus CDS
      CCDS10313.1
      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
      Related
      ENSP00000454137.1, ENST00000558494.5
      Conserved Domains (2) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1234
      zf-A20; A20-like zinc finger
    2. NM_001242912.2NP_001229841.1  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_001229841.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
      Source sequence(s)
      AC092701, AW571396, BX363429, DB050060
      Consensus CDS
      CCDS10313.1
      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
      Related
      ENSP00000479071.1, ENST00000613266.4
      Conserved Domains (2) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1234
      zf-A20; A20-like zinc finger
    3. NM_001242913.2NP_001229842.1  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_001229842.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
      Source sequence(s)
      AC092701, AW571396, CN428457
      Consensus CDS
      CCDS10313.1
      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
      Related
      ENSP00000478129.1, ENST00000616533.4
      Conserved Domains (2) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1234
      zf-A20; A20-like zinc finger
    4. NM_001242914.2NP_001229843.1  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_001229843.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
      Source sequence(s)
      AC092701, AW571396, BG720174, BI562073
      Consensus CDS
      CCDS10313.1
      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
      Related
      ENSP00000484971.1, ENST00000618205.4
      Conserved Domains (2) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1234
      zf-A20; A20-like zinc finger
    5. NM_001242915.2NP_001229844.1  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_001229844.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
      Source sequence(s)
      AF261138, AW571396, DA091136
      Consensus CDS
      CCDS10313.1
      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
      Related
      ENSP00000453291.1, ENST00000559835.5
      Conserved Domains (2) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1234
      zf-A20; A20-like zinc finger
    6. NM_001242916.2NP_001229845.1  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_001229845.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-7 all encode isoform a.
      Source sequence(s)
      AC092701, AW571396, DA091136, DR762914
      Consensus CDS
      CCDS10313.1
      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
      Related
      ENSP00000453709.1, ENST00000559775.5
      Conserved Domains (2) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1234
      zf-A20; A20-like zinc finger
    7. NM_001242917.2NP_001229846.1  AN1-type zinc finger protein 6 isoform b

      See identical proteins and their annotated locations for NP_001229846.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC092701, AF061739, AW571396, DB050060
      Consensus CDS
      CCDS58395.1
      UniProtKB/TrEMBL
      B2R6N3
      Related
      ENSP00000454152.1, ENST00000559157.6
      Conserved Domains (3) summary
      smart00154
      Location:137174
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1235
      zf-A20; A20-like zinc finger
      pfam06484
      Location:25130
      Ten_N; Teneurin Intracellular Region
    8. NM_001242918.2NP_001229847.1  AN1-type zinc finger protein 6 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC092701, AW571396, BP231220, DB050060
      UniProtKB/TrEMBL
      H3BM82
      Related
      ENSP00000454273.1, ENST00000564367.5
      Conserved Domains (3) summary
      pfam01754
      Location:1235
      zf-A20; A20-like zinc finger
      pfam06484
      Location:25117
      Ten_N; Teneurin Intracellular Region
      cl01438
      Location:118148
      zf-AN1; AN1-like Zinc finger
    9. NM_001242919.1NP_001229848.1  AN1-type zinc finger protein 6 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and uses two alternate in-frame splice sites in the central coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC092701, AW571396, BP234517
      UniProtKB/TrEMBL
      B2R6N3
      Conserved Domains (2) summary
      smart00154
      Location:122159
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1235
      zf-A20; A20-like zinc finger
    10. NM_019006.4NP_061879.2  AN1-type zinc finger protein 6 isoform a

      See identical proteins and their annotated locations for NP_061879.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-7 all encode isoform a.
      Source sequence(s)
      AW571396, BC005283, DB050060
      Consensus CDS
      CCDS10313.1
      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
      Related
      ENSP00000261749.6, ENST00000261749.11
      Conserved Domains (2) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1234
      zf-A20; A20-like zinc finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      80058951..80138393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432697.1XP_047288653.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
    2. XM_024449959.2XP_024305727.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
      Conserved Domains (2) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1234
      zf-A20; A20-like zinc finger
    3. XM_024449956.2XP_024305724.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
      Conserved Domains (2) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1234
      zf-A20; A20-like zinc finger
    4. XM_024449963.2XP_024305731.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
      Conserved Domains (2) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1234
      zf-A20; A20-like zinc finger
    5. XM_047432696.1XP_047288652.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
    6. XM_047432695.1XP_047288651.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
    7. XM_011521684.3XP_011519986.1  AN1-type zinc finger protein 6 isoform X1

      See identical proteins and their annotated locations for XP_011519986.1

      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
      Conserved Domains (2) summary
      smart00154
      Location:149186
      ZnF_AN1; AN1-like Zinc finger
      pfam01754
      Location:1234
      zf-A20; A20-like zinc finger
    8. XM_047432694.1XP_047288650.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      77923092..78001808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378223.1XP_054234198.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
    2. XM_054378226.1XP_054234201.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
    3. XM_054378225.1XP_054234200.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
    4. XM_054378224.1XP_054234199.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3
    5. XM_054378222.1XP_054234197.1  AN1-type zinc finger protein 6 isoform X1

      UniProtKB/Swiss-Prot
      D3DW92, D3DW94, O95792, Q6FIF0, Q9BQF7, Q9GZY3
      UniProtKB/TrEMBL
      B2R6N3