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    HDGFL1 HDGF like 1 [ Homo sapiens (human) ]

    Gene ID: 154150, updated on 27-Nov-2024

    Summary

    Official Symbol
    HDGFL1provided by HGNC
    Official Full Name
    HDGF like 1provided by HGNC
    Primary source
    HGNC:HGNC:21095
    See related
    Ensembl:ENSG00000112273 AllianceGenome:HGNC:21095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HRP-1; PWWP1; Hdgfrp1; dJ309H15.1
    Summary
    Predicted to be involved in chromatin remodeling. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
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    Genomic context

    See HDGFL1 in Genome Data Viewer
    Location:
    6p22.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (22569566..22571666)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (22442013..22444113)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (22569795..22571895)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:22221433-22222281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:22223143-22223644 Neighboring gene NGRN pseudogene 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:22313984-22314538 Neighboring gene uncharacterized LOC105374971 Neighboring gene prolactin Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:22441843-22443042 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:22443327-22443827 Neighboring gene MPRA-validated peak5731 silencer Neighboring gene uncharacterized LOC105374973 Neighboring gene uncharacterized LOC102724736 Neighboring gene long intergenic non-protein coding RNA 3005

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    hepatoma-derived growth factor-like protein 1
    Names
    HDGF (hepatoma-derived growth factor) like
    PWWP domain containing 1
    PWWP domain-containing protein 1
    hepatoma derived growth factor-like 1
    testicular tissue protein Li 84

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138574.4NP_612641.2  hepatoma-derived growth factor-like protein 1

      See identical proteins and their annotated locations for NP_612641.2

      Status: VALIDATED

      Source sequence(s)
      AL033539
      Consensus CDS
      CCDS34347.1
      UniProtKB/Swiss-Prot
      Q5TGJ6, Q96MJ6
      UniProtKB/TrEMBL
      A0A140VJK8
      Related
      ENSP00000442129.1, ENST00000510882.4
      Conserved Domains (2) summary
      cd05834
      Location:985
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      PHA00666
      Location:81159
      PHA00666; putative protease

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      22569566..22571666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      22442013..22444113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)