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    ULBP1 UL16 binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 80329, updated on 9-Dec-2024

    Summary

    Official Symbol
    ULBP1provided by HGNC
    Official Full Name
    UL16 binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:14893
    See related
    Ensembl:ENSG00000111981 MIM:605697; AllianceGenome:HGNC:14893
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    N2DL-1; RAET1I; NKG2DL1
    Summary
    The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in testis (RPKM 1.6), lung (RPKM 0.5) and 3 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ULBP1 in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149963943..149973715)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (151163286..151173058)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150285079..150294851)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:150259106-150259796 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:150259797-150260487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17672 Neighboring gene UL16 binding protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150274681-150275653 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150275654-150276625 Neighboring gene Sharpr-MPRA regulatory region 14768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150285415-150285954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150286496-150287035 Neighboring gene basic transcription factor 3 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17673 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:150312121-150312704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17674 Neighboring gene retinoic acid early transcript 1K (pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef downregulates cell surface expression of MICA, ULBP1 and ULBP2 in natural killer (NK) cells PubMed
    Vif vif A3G upregulates NKG2D ligands through an ATM pathway and in which HIV-1 Vif counteracts this upregulation by decreasing A3G expression PubMed
    vif Vpr-dependent induction and Vif-mediated attenuation of NKG2D ligands are required for Chk2 phosphorylation in HIV infection PubMed
    vif HIV-1 Vif expression in HIV-1 infected cells results in less HIV-1 Vpr-dependent upregulation of NKG2D ligands PubMed
    Vpr vpr HIV-1-Vpr induced upregulation of NKG2D ligands in HIV-infected T cells by activating UNG2-dependent repair of uridine-containing DNA PubMed
    vpr HIV-1 Vpr upregulates NKG2D ligands via the ATR pathway PubMed
    vpr Vpr-dependent induction and Vif-mediated attenuation of NKG2D ligands are required for Chk2 phosphorylation in HIV infection PubMed
    vpr HIV-1 Vif expression in HIV-1 infected cells results in less HIV-1 Vpr-dependent upregulation of NKG2D ligands PubMed
    vpr Upregulation of NKG2D ligands is dependent on HIV-1 Vpr-mediated activation of the TAR DNA damage/stress pathway, which requires the recruitment of the Cul4/DDB1/DCAF1 E3 ubiquitin ligase complex PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables natural killer cell lectin-like receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    UL16-binding protein 1
    Names
    NKG2D ligand 1
    alcan-beta
    retinoic acid early transcript 1I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317089.2NP_001304018.1  UL16-binding protein 1 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK292519, AL355497, BC035416, BM670923, DB462306
      UniProtKB/Swiss-Prot
      Q9BZM6
    2. NM_025218.4NP_079494.1  UL16-binding protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_079494.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK292519, AL355497, BC035416, BM670923
      Consensus CDS
      CCDS5223.1
      UniProtKB/Swiss-Prot
      Q5VY81, Q8IZW3, Q8IZX6, Q9BZM6
      Related
      ENSP00000229708.2, ENST00000229708.4
      Conserved Domains (1) summary
      cl08246
      Location:31205
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RNA

    1. NR_133659.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of the first exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK292519, AL355497, BM670923, KT591165

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      149963943..149973715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011322.2XP_016866811.1  UL16-binding protein 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      151163286..151173058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356468.1XP_054212443.1  UL16-binding protein 1 isoform X1