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    MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like [ Homo sapiens (human) ]

    Gene ID: 25902, updated on 3-Dec-2024

    Summary

    Official Symbol
    MTHFD1Lprovided by HGNC
    Official Full Name
    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 likeprovided by HGNC
    Primary source
    HGNC:HGNC:21055
    See related
    Ensembl:ENSG00000120254 MIM:611427; AllianceGenome:HGNC:21055
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FTHFSDC1; MTC1THFS; dJ292B18.2
    Summary
    The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
    Expression
    Ubiquitous expression in ovary (RPKM 2.3), thyroid (RPKM 2.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MTHFD1L in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (150865702..151101887)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (152066259..152302476)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (151186838..151423023)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene pleckstrin homology and RhoGEF domain containing G1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:151169980-151171179 Neighboring gene uncharacterized LOC124901431 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:151177675-151178874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17684 Neighboring gene PDCL3 pseudogene 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:151227577-151228082 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:151243887-151244135 Neighboring gene RNA, U6 small nuclear 302, pseudogene Neighboring gene ADP ribosylation factor like GTPase 4A pseudogene 5 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:151330831-151331567 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:151330092-151330830 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:151357191-151358390 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:151381202-151382401 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90950 Neighboring gene uncharacterized LOC124901432 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:151410975-151411808 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:151413024-151414223 Neighboring gene Sharpr-MPRA regulatory region 10334 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:151450407-151451398 Neighboring gene ribosomal protein L32 pseudogene 16 Neighboring gene microRNA 12131 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:151485034-151485534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:151485535-151486035 Neighboring gene uncharacterized LOC102723831 Neighboring gene RNA, U6 small nuclear 300, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.
    EBI GWAS Catalog
    Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
    EBI GWAS Catalog
    Genomewide association analysis of coronary artery disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif interacts with MTHFD1L; interaction predicted to be relevant to purine pyrimidine biosynthesis PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21145, DKFZp586G1517

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables formate-tetrahydrofolate ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables formate-tetrahydrofolate ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in 10-formyltetrahydrofolate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in 10-formyltetrahydrofolate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in embryonic neurocranium morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in embryonic viscerocranium morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in folic acid-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in formate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neural tube closure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane HDA PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Names
    10-formyl-THF synthetase
    formyltetrahydrofolate synthetase domain containing 1
    NP_001229696.1
    NP_001229697.1
    NP_001229698.1
    NP_001337415.1
    NP_001337416.1
    NP_001337417.1
    NP_001337418.1
    NP_001337419.1
    NP_001337420.1
    NP_001337421.1
    NP_001337422.1
    NP_056255.2
    XP_005266964.1
    XP_005266968.1
    XP_011534031.1
    XP_011534032.1
    XP_011534033.1
    XP_011534034.1
    XP_011534035.1
    XP_011534039.1
    XP_011534040.1
    XP_016866191.1
    XP_016866192.1
    XP_024302163.1
    XP_024302164.1
    XP_047274565.1
    XP_047274566.1
    XP_047274567.1
    XP_047274568.1
    XP_047274569.1
    XP_047274570.1
    XP_047274571.1
    XP_047274572.1
    XP_047274573.1
    XP_047274574.1
    XP_047274575.1
    XP_054211073.1
    XP_054211074.1
    XP_054211075.1
    XP_054211076.1
    XP_054211077.1
    XP_054211078.1
    XP_054211079.1
    XP_054211080.1
    XP_054211081.1
    XP_054211082.1
    XP_054211083.1
    XP_054211084.1
    XP_054211085.1
    XP_054211086.1
    XP_054211087.1
    XP_054211088.1
    XP_054211089.1
    XP_054211090.1
    XP_054211091.1
    XP_054211092.1
    XP_054211093.1
    XP_054211094.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029185.2 RefSeqGene

      Range
      5024..241209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001242767.2NP_001229696.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_001229696.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC110319, BC144368, DB727926
      Consensus CDS
      CCDS75535.1
      UniProtKB/TrEMBL
      B7ZM99
      Related
      ENSP00000478253.1, ENST00000611279.4
      Conserved Domains (4) summary
      cd05212
      Location:193336
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:353979
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:72289
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:74180
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    2. NM_001242768.2NP_001229697.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK315378, BC110319, DA195967
      Consensus CDS
      CCDS75536.1
      UniProtKB/TrEMBL
      A0A087WVM4, B2RD24
      Related
      ENSP00000479539.1, ENST00000618312.4
      Conserved Domains (4) summary
      cd05212
      Location:127270
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:287913
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:9223
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:10114
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    3. NM_001242769.3NP_001229698.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 4 precursor

      See identical proteins and their annotated locations for NP_001229698.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus and lacks a single internal aa compared to isoform 1. Isoform 4 is thought to lack THF synthase activity.
      Source sequence(s)
      AW593866, AY374131, DB727926
      Consensus CDS
      CCDS56457.1
      UniProtKB/Swiss-Prot
      Q6UB35
      Related
      ENSP00000356276.4, ENST00000367307.8
      Conserved Domains (3) summary
      COG0190
      Location:72228
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:74180
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      cl21454
      Location:193260
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. NM_001350486.1NP_001337415.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL035086, AL049694, AL133260
      UniProtKB/TrEMBL
      B2RD24
      Conserved Domains (3) summary
      cd05212
      Location:127269
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:286912
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:9222
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    5. NM_001350487.2NP_001337416.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL035086, AL049694, AL133260
      UniProtKB/TrEMBL
      B2RD24
      Conserved Domains (3) summary
      cd05212
      Location:83225
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:242868
      PLN02759; Formate--tetrahydrofolate ligase
      pfam00763
      Location:970
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    6. NM_001350488.3NP_001337417.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AL035086
      Conserved Domains (2) summary
      COG0190
      Location:72229
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      cl25423
      Location:193261
      NAD_bind_amino_acid_DH; NAD(P) binding domain of amino acid dehydrogenase-like proteins
    7. NM_001350489.3NP_001337418.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AL035086
      Conserved Domains (1) summary
      COG0190
      Location:72213
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    8. NM_001350490.1NP_001337419.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL049694, AL133260
      Conserved Domains (1) summary
      pfam01268
      Location:2270
      FTHFS; Formate--tetrahydrofolate ligase
    9. NM_001350491.3NP_001337420.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL035086
      Conserved Domains (2) summary
      COG0190
      Location:9119
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      cl21454
      Location:83151
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    10. NM_001350492.2NP_001337421.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 12, encodes isoform 11.
      Source sequence(s)
      AL035086, AL049694, AL133260
      UniProtKB/TrEMBL
      B2RD24
      Conserved Domains (3) summary
      cd05212
      Location:83226
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:243869
      PLN02759; Formate--tetrahydrofolate ligase
      pfam00763
      Location:970
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    11. NM_001350493.1NP_001337422.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variant 11, encodes isoform 11.
      Source sequence(s)
      AL035086, AL049694, AL133260
      UniProtKB/TrEMBL
      B2RD24
      Conserved Domains (3) summary
      cd05212
      Location:83226
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:243869
      PLN02759; Formate--tetrahydrofolate ligase
      pfam00763
      Location:970
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    12. NM_015440.5NP_056255.2  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_056255.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AY374130, BC110319, DB727926
      Consensus CDS
      CCDS5228.1
      UniProtKB/Swiss-Prot
      Q2TBF3, Q6UB35, Q8WVW0, Q96HG8, Q9H789, Q9UFU8
      Related
      ENSP00000356290.3, ENST00000367321.8
      Conserved Domains (4) summary
      cd05212
      Location:193335
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:352978
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:72288
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:74180
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain

    RNA

    1. NR_146719.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL035086, AL049694, AL133260
    2. NR_146720.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL035086, AL049694, AL133260

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      150865702..151101887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010702.3XP_016866191.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      B7ZM99
      Conserved Domains (4) summary
      cd05212
      Location:193336
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:353979
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:72289
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:74180
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    2. XM_017010703.3XP_016866192.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      B7ZM99
      Conserved Domains (4) summary
      cd05212
      Location:193336
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:353979
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:72289
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:74180
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    3. XM_011535729.4XP_011534031.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X4

      Conserved Domains (4) summary
      cd05212
      Location:193336
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:353952
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:72289
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:74180
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    4. XM_047418610.1XP_047274566.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X5

    5. XM_047418609.1XP_047274565.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1

    6. XM_005266907.6XP_005266964.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X2

      Conserved Domains (4) summary
      cd05212
      Location:193335
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:352949
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:72288
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:74180
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    7. XM_047418616.1XP_047274572.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X14

    8. XM_047418615.1XP_047274571.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X13

    9. XM_047418614.1XP_047274570.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X12

    10. XM_011535737.4XP_011534039.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X15

      Conserved Domains (4) summary
      cd05212
      Location:193336
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      COG0190
      Location:72289
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:74180
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      cl21455
      Location:353709
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    11. XM_011535738.4XP_011534040.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X16

      Conserved Domains (4) summary
      cd05212
      Location:193336
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      COG0190
      Location:72289
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:74180
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      cl21455
      Location:353709
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    12. XM_047418617.1XP_047274573.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X17

    13. XM_005266911.6XP_005266968.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X18

      Conserved Domains (4) summary
      cd05212
      Location:193336
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      COG0190
      Location:72289
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:74180
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
      cl21455
      Location:353605
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    14. XM_024446396.2XP_024302164.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X19

      Conserved Domains (3) summary
      cd05212
      Location:193336
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      COG0190
      Location:72289
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      cl21455
      Location:353420
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    15. XM_047418618.1XP_047274574.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X20

    16. XM_011535730.2XP_011534032.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X8

      Conserved Domains (4) summary
      cd05212
      Location:127270
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:287884
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:9223
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:10114
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    17. XM_011535731.3XP_011534033.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X9

      Conserved Domains (4) summary
      cd05212
      Location:127269
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:286883
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:9222
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:10114
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    18. XM_047418613.1XP_047274569.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X11

      UniProtKB/TrEMBL
      B2RD24
    19. XM_047418612.1XP_047274568.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X10

      UniProtKB/TrEMBL
      B2RD24
    20. XM_047418611.1XP_047274567.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X6

    21. XM_011535733.3XP_011534035.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X10

      See identical proteins and their annotated locations for XP_011534035.1

      UniProtKB/TrEMBL
      B2RD24
      Conserved Domains (4) summary
      cd05212
      Location:83226
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:243840
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:9179
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:970
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    22. XM_011535732.3XP_011534034.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X10

      See identical proteins and their annotated locations for XP_011534034.1

      UniProtKB/TrEMBL
      B2RD24
      Conserved Domains (4) summary
      cd05212
      Location:83226
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:243840
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:9179
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
      pfam00763
      Location:970
      THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    23. XM_024446395.1XP_024302163.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X7

      Conserved Domains (3) summary
      cd05212
      Location:158300
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:317943
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:40253
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    24. XM_047418619.1XP_047274575.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X21

      Conserved Domains (1) summary
      pfam01268
      Location:2270
      FTHFS; Formate--tetrahydrofolate ligase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      152066259..152302476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355100.1XP_054211075.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      B7ZM99
    2. XM_054355101.1XP_054211076.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X4

    3. XM_054355102.1XP_054211077.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X5

    4. XM_054355098.1XP_054211073.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1

    5. XM_054355099.1XP_054211074.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X2

    6. XM_054355113.1XP_054211088.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X14

    7. XM_054355112.1XP_054211087.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X13

    8. XM_054355111.1XP_054211086.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X12

    9. XM_054355114.1XP_054211089.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X15

    10. XM_054355115.1XP_054211090.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X16

    11. XM_054355116.1XP_054211091.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X17

    12. XM_054355117.1XP_054211092.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X18

    13. XM_054355118.1XP_054211093.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X19

    14. XM_054355119.1XP_054211094.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X20

    15. XM_054355105.1XP_054211080.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X8

    16. XM_054355106.1XP_054211081.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X9

    17. XM_054355110.1XP_054211085.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X11

      UniProtKB/TrEMBL
      B2RD24
    18. XM_054355109.1XP_054211084.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X10

      UniProtKB/TrEMBL
      B2RD24
    19. XM_054355103.1XP_054211078.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X6

    20. XM_054355108.1XP_054211083.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X10

      UniProtKB/TrEMBL
      B2RD24
    21. XM_054355107.1XP_054211082.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X10

      UniProtKB/TrEMBL
      B2RD24
    22. XM_054355104.1XP_054211079.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X7