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    LRP11 LDL receptor related protein 11 [ Homo sapiens (human) ]

    Gene ID: 84918, updated on 27-Nov-2024

    Summary

    Official Symbol
    LRP11provided by HGNC
    Official Full Name
    LDL receptor related protein 11provided by HGNC
    Primary source
    HGNC:HGNC:16936
    See related
    Ensembl:ENSG00000120256 AllianceGenome:HGNC:16936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MANSC3; bA350J20.3
    Summary
    Enables phosphoprotein binding activity. Predicted to be involved in several processes, including response to cold; response to immobilization stress; and response to water deprivation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in prostate (RPKM 11.0), brain (RPKM 10.7) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LRP11 in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149818757..149864359, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (151018123..151063700, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150139893..150185495, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase Neighboring gene uncharacterized LOC107986660 Neighboring gene BTB domain containing 10 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25268 Neighboring gene RAET1E-LRP11 readthrough Neighboring gene uncharacterized LOC124901427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150185306-150185806 Neighboring gene RAET1E antisense RNA 1 Neighboring gene chaperonin containing TCP1 subunit 7 pseudogene 1 Neighboring gene retinoic acid early transcript 1E

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of low density lipoprotein receptor-related protein 11 (LRP11) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough RAET1E-LRP11

    Readthrough gene: RAET1E-LRP11, Included gene: RAET1E

    Clone Names

    • FLJ14735, MGC39092

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphoprotein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in multicellular organismal response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cold IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to immobilization stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to water deprivation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    low-density lipoprotein receptor-related protein 11
    Names
    LRP-11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410946.1NP_001397875.1  low-density lipoprotein receptor-related protein 11 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL355312
      Consensus CDS
      CCDS94018.1
      UniProtKB/TrEMBL
      Q5VYB9
      Related
      ENSP00000356338.2, ENST00000367368.3
    2. NM_032832.6NP_116221.3  low-density lipoprotein receptor-related protein 11 isoform 1 precursor

      See identical proteins and their annotated locations for NP_116221.3

      Status: VALIDATED

      Source sequence(s)
      AK027641, AK299599, AL355312, BC025239, BC043141, N91459
      Consensus CDS
      CCDS5220.1
      UniProtKB/Swiss-Prot
      Q5VYC0, Q86VZ4, Q96SN6
      Related
      ENSP00000239367.2, ENST00000239367.7
      Conserved Domains (3) summary
      smart00765
      Location:84184
      MANEC; The MANEC domain, formerly called MANSC
      cd00112
      Location:310344
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00146
      Location:208296
      PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      149818757..149864359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      151018123..151063700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)