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    RAET1E retinoic acid early transcript 1E [ Homo sapiens (human) ]

    Gene ID: 135250, updated on 27-Nov-2024

    Summary

    Official Symbol
    RAET1Eprovided by HGNC
    Official Full Name
    retinoic acid early transcript 1Eprovided by HGNC
    Primary source
    HGNC:HGNC:16793
    See related
    Ensembl:ENSG00000164520 MIM:609243; AllianceGenome:HGNC:16793
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RL-4; LETAL; ULBP4; N2DL-4; NKG2DL4; RAET1E2; bA350J20.7
    Summary
    This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
    Expression
    Biased expression in esophagus (RPKM 7.0) and skin (RPKM 2.7) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RAET1E in Genome Data Viewer
    Location:
    6q25.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149883179..149898113, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (151082513..151097456, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150204315..150219249, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RAET1E-LRP11 readthrough Neighboring gene LDL receptor related protein 11 Neighboring gene uncharacterized LOC124901427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:150185306-150185806 Neighboring gene RAET1E antisense RNA 1 Neighboring gene chaperonin containing TCP1 subunit 7 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 9442 Neighboring gene multimerin 2 pseudogene Neighboring gene retinoic acid early transcript 1F (pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough RAET1E-LRP11

    Readthrough gene: RAET1E-LRP11, Included gene: LRP11

    Clone Names

    • MGC125308, MGC125309

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables natural killer cell lectin-like receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    retinoic acid early transcript 1E
    Names
    NKG2D ligand 4
    RAE-1-like transcript 4
    UL16-binding protein 4
    lymphocyte effector toxicity activation ligand

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029833.2 RefSeqGene

      Range
      5000..19934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001243325.2NP_001230254.1  retinoic acid early transcript 1E isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL355312
      Consensus CDS
      CCDS59044.1
      UniProtKB/TrEMBL
      Q3ZAR2
      Related
      ENSP00000356332.3, ENST00000367363.3
      Conserved Domains (1) summary
      cl08246
      Location:26159
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    2. NM_001243327.2NP_001230256.1  retinoic acid early transcript 1E isoform 3 precursor

      See identical proteins and their annotated locations for NP_001230256.1

      Status: REVIEWED

      Source sequence(s)
      AL355312
      Consensus CDS
      CCDS59042.1
      UniProtKB/TrEMBL
      A0A0G3VSE5
      Related
      ENSP00000432366.1, ENST00000529948.1
      Conserved Domains (1) summary
      cl08246
      Location:30195
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    3. NM_001243328.3NP_001230257.1  retinoic acid early transcript 1E isoform 4 precursor

      See identical proteins and their annotated locations for NP_001230257.1

      Status: REVIEWED

      Source sequence(s)
      AL355312
      Consensus CDS
      CCDS59043.1
      UniProtKB/TrEMBL
      A0A0G3VSE5
      Related
      ENSP00000437067.1, ENST00000532335.5
      Conserved Domains (1) summary
      cl08246
      Location:30195
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    4. NM_001394056.1NP_001380985.1  retinoic acid early transcript 1E isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AL355312
      UniProtKB/TrEMBL
      A0A2P1NST7
      Conserved Domains (1) summary
      cl08246
      Location:30195
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    5. NM_001394057.1NP_001380986.1  retinoic acid early transcript 1E isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL355312
      Consensus CDS
      CCDS5221.1
      UniProtKB/Swiss-Prot
      A6YF59, Q5VYB7, Q5VYB8, Q8TD07, Q8TEZ2, Q96L41
      UniProtKB/TrEMBL
      Q3ZAR2
      Related
      ENSP00000349709.4, ENST00000357183.9
      Conserved Domains (1) summary
      cl08246
      Location:30195
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    6. NM_139165.3NP_631904.1  retinoic acid early transcript 1E isoform 1 precursor

      See identical proteins and their annotated locations for NP_631904.1

      Status: REVIEWED

      Source sequence(s)
      AL355312
      Consensus CDS
      CCDS5221.1
      UniProtKB/Swiss-Prot
      A6YF59, Q5VYB7, Q5VYB8, Q8TD07, Q8TEZ2, Q96L41
      UniProtKB/TrEMBL
      Q3ZAR2
      Conserved Domains (1) summary
      cl08246
      Location:30195
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      149883179..149898113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      151082513..151097456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)